Novel imantib resistance mechanisms in chronic myloid leukemia

Novel imantib resistance mechanisms in chronic myloid leukemia

In my research, I found that the compensatory activation of PI3K/AKT/mTor signaling pathway contributes early imatinib resistance in LAMA cell models. We also found that the auto/paracrine of GM-CSF by imatinib resistant leukemic cells confers to potent imatinib and nilotinib resistance. These findi...

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Detalhes bibliográficos
Autor principal: Wang, Ying
Outros Autores: Neubauer, Andreas (Prof. Dr.) (Orientador)
Formato: Dissertation
Idioma:inglês
Publicado em: Philipps-Universität Marburg 2007
Assuntos:
Imatinib resistance
Chronic myeloid leukaemia
Medizin
GM-CSF
PI3K/Akt pathway
Conditioned medium
Medical sciences Medicine
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Detalhes do Exemplar
Número de Chamada: urn:nbn:de:hebis:04-z2007-03098
Data de Publicação: 2007-05-09
Datum der Annahme: 2007-04-26
Downloads: 19 (2024), 32 (2023), 53 (2022), 71 (2021), 46 (2020), 49 (2019), 29 (2018)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
Acessar a URL: https://archiv.ub.uni-marburg.de/diss/z2007/0309
https://doi.org/10.17192/z2007.0309

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