The surfactin biosynthetic complex of Bacillus subtilis: COM domain-mediated biocombinatorial synthesis, and single step purification of native multi-modular NRPSs and multi-enzyme complexes

The surfactin biosynthetic complex of Bacillus subtilis: COM domain-mediated biocombinatorial synthesis, and single step purification of native multi-modular NRPSs and multi-enzyme complexes

Most biosynthetic templates for the assembly of peptide natural products are composed of two or more nonribosomal peptide synthetases (NRPSs). For example, the surfactin biosynthetic complex consists of three NRPSs (SrfA-A, SrfA-B, and SrfA-C), which are encoded by the polycistronic srfA operon with...

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Bibliographische Detailangaben
1. Verfasser: Chiocchini, Claudia
Beteiligte: Buckel, Wolfgang (Prof.) (BetreuerIn (Doktorarbeit))
Format: Dissertation
Sprache:Englisch
Veröffentlicht: Philipps-Universität Marburg 2006
Schlagworte:
Protein-protein communication
Multienzymkomplex
Multienzyme complexes
COM domains
Biochemistry, molecular biology
NRPS
Biowissenschaften, Biologie
COM Domäne
Protein-Protein-Wechselwirkung
Life sciences
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