Klonale experimentelle autoimmune Enzephalomyelitis: T-Zell-Charakteristika bestimmen die Läsionspathologie

Die Multiple Sklerose (MS) ist die häufigste chronisch entzündliche Entmarkungserkrankung in Nordeuropa und Nordamerika. Sie ist klinisch und histopathologisch eine heterogene Erkrankung mit unterschiedlichen Krankheitsverläufen und histopathologischen Läsionen. Die Experimentelle Autoimmune Enzepha...

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Bibliographic Details
Main Author: Nessler, Stefan
Contributors: Sommer, N. (Prof. Dr.) (Thesis advisor)
Format: Dissertation
Language:German
Published: Philipps-Universität Marburg 2006
Nervenheilkunde
Subjects:
EAE
Online Access:PDF Full Text
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Table of Contents: Experimental autoimmune encephalomyelitis (EAE)is a well known animal model of Multiple sclerosis. In this study EAE was induced by the adoptive transfer of PLP139-51 specific T cell clones into SJL/J mice. Encephalitogenic Th1 T cell clones induced the typical mononuclear EAE lesions in the spinal cord and optic nerve, whereas EAE lesions induced by a Th2 type T cell clone were characterized by eosinophilic infiltrates, with abundant Ig deposition and considerable tissue destruction. Antibody responses in T cell clone transfered animals revealed early epitope spreading to other myelin antigens.