Structural and Functional Studies of tRNA-Guanine Transglycosylase: A putative Drug Target for Shigellosis Therapy
In this study structure-based drug design approaches for Zymomonas mobilis tRNA - guanine transglycosylase (TGT) are presented. In Shigella sp., the causative agent of bacterial shigellosis, TGT is involved in pathogenicity. Concerning the amino acid sequence, TGTs from both genera are highly h...
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