Untersuchung eines möglichen neuroprotektiven Effektes der Kainsäure- und Chinolinsäureläsion des Nucleus subthalamicus auf dopaminerge Neurone der Substantia nigra im 6-Hydroxydopamin- und im 3-Nitropropionsäure-Parkinson-Tiermodell der Ratte.

The idiopathic Parkinson Syndrome is one of the most common neurologic diseases. A progressive loss of dopaminergic nigrostriatal neurons in the Substantia nigra pars compacta leads to a dopamine deficite in the Striatum which, as we these days suppose the basal ganglias are organized, results in an unrestrained activity of Nucleus subthalamicus and in the following to hyperactivity of the inhibitory GABA-neurons located in the medial segment of the Pallidum projecting in the Thalamus area. This results in decreasing excitatory thalamic function on the motor cortex. Recently excitatory glutamatergic neurons between Subthalamic nucleus and Substantia nigra are postulated, in the course of which neurotoxic qualities of glutamate damaging metabolic weakened dopaminergic neurons of Substantia nigra may play a major role in the ethiology of ParkinsonsŽdesease. For some years now, chronic high-frequency stimulation of Nucleus Subthalamicus or medial Pallidum or thermocoagulatory lesion of medial Pallidum is in clinical use for patients with progressive ParkinsonsŽdesease. The exact mode of working of these therapeutic options is still unknown. In this work we tried to investigate the neuroprotective effect of Kainic- and Quinolinic acid-lesions of Nucleus Subthalamicus on dopaminergic neurons of Substantia nigras pars compacta in the subacute 6-Hydroxydopamine and in 3-Nitropropionic acid Parkinson-model in rats. We were not able to reproduce the results of other groups, postulating that a subthalamic nucleus lesion shows neuroprotective effects on populations of neurons in Substantia nigra. It seems to be necessary to repeat the experiments with a higher number of cases, especially as there might result clinical-therapeutic consequences with effect on the prognosis of affected patients.