Prognostische Bedeutung morphometrischer endomyokardialer Biopsieanalysen bei Patienten mit dilatativer Kardiomyopathie

In der vorliegenden Untersuchung wurde die prognostische Bedeutung einer quantitativen morphometrischen Analyse von Endomyocardbiopsien bei 124 Patienten mit dilatativer Kardiomyopathie untersucht, da zum jetzigen Zeitpunkt kontroverse Ansichten über die prognostische Signifikanz...

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Bibliographic Details
Main Author: Rudolph, Sylvia
Contributors: Grimm, Wolfram (Prof. Dr. med) (Thesis advisor)
Format: Dissertation
Language:German
Published: Philipps-Universität Marburg 2004
Innere Medizin
Subjects:
DCM
Online Access:PDF Full Text
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Table of Contents: BACKGROUND: To date, considerable controversy exists on the prognostic significance of morphometric endomyocardial biopsy findings in patients with idiopathic dilated cardiomyopathy (IDC). METHODS: Quantitative analyses of interstitial structured tissue, myofibril volume fraction, and myocytic fiber diameters of left ventricular endomyocardial biopsy specimens were performed in 124 patients with IDC. RESULTS: During 51 +/- 22 months follow-up after left ventricular endomyocardial biopsy, major arrhythmic events, defined as sustained ventricular tachycardia (VT), ventricular fibrillation (VF), or sudden cardiac death, were observed in 24 patients (19%). Death from any cause or heart transplant was observed in 39 patients (31%). The amount of interstitial structured tissue, myofibril volume fraction, and myocytic fiber diameters determined from left ventricular endomyocardial biopsy specimens did not differ significantly between patients with and patients without major arrhythmic events or between patients with and patients without transplant-free survival during follow-up. CONCLUSIONS: Quantitative analysis of the amount of interstitial structured tissue, myofibril volume fraction, and myocytic fiber diameters in left ventricular endomyocardial biopsy specimens does not appear to be useful for predicting arrhythmic events and transplant-free survival in IDC.