Prognosefaktoren beim nichtkleinzelligen Bronchialkarzinom - Inzidenz von p53, bcl-2, HER-2, HSP27, HSP60 und HSP70 in nichtkleinzelligen Bronchialkarzinomen des Stadiums IIIA

Das Bronchialkarzinom stellt weltweit 25% aller durch Tumoren bedingten Todesfälle dar. Die Prognose von Patienten mit einem NSCLC Stadium IIIA konnte durch den Einsatz multimodaler Therapien in den letzten 5 Jahren deutlich verbessert werden. Dennoch beträgt die 5-Jahresüberlebenszeit dieser Patien...

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Bibliographic Details
Main Author: Schwindel, Uwe
Format: Dissertation
Language:German
Published: Philipps-Universität Marburg 2003
Innere Medizin
Subjects:
p53
Online Access:PDF Full Text
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Table of Contents: Lung cancer is one of leading causes of cancer death in the world. Patients with similar stage of disease show differences in probabilities of survival. This illustrates the need to identify new prognostic factors that may help to optimize therapeutic efforts for each individual patient. The aim of this study was to document the incidence of p53, bcl-2, HER-2, HSP27, HSP60 and HSP70 in stage IIIA non-small cell lung carcinomas. We investigated 34 non-small lung cancers for prognostic factors overexpression by immunohistochemistry. Of the 34 NSCLC tissues studied, the presence of p53 was demonstrated in 16 of 34 (47,05 %), HER-2 in 3 of 30 (10 %), HSP27 in 29 of 34 (85,29 %), HSP60 in 21 of 34 (61,76 %) and HSP70 in 8 of 34 tissues (23,52 %). Noteworthy there was no clear overexpression of bcl-2 in any of the investigated tissues. Statistical comparison revealed no significant differences between protein overexpression and the patients clinical characteristics.