PAC1 deficiency reduces chondrogenesis in atherosclerotic lesions of hypercholesterolemic ApoE-deficient mice

PAC1 deficiency reduces chondrogenesis in atherosclerotic lesions of hypercholesterolemic ApoE-deficient mice

Induction of chondrogenesis is associated with progressive atherosclerosis. Deficiency of the ADCYAP1 gene encoding pituitary adenylate cyclase-activating peptide (PACAP) aggravates atherosclerosis in ApoE deficient (ApoE−/−) mice. PACAP signaling regulates chondrogenesis and osteogenesis during car...

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Autors principals: Blümm, C., Bonaterra, G. A., Schwarzbach, H., Eiden, L. E., Weihe, E., Kinscherf, R.
Format: Article
Idioma:anglès
Publicat: Philipps-Universität Marburg 2024
Matèries:
Medizin
Macrophages, Vascular calcification
Chondrogenic transcription factor
Collagen
Cardiovascular disease
Atherosclerosis
Vascular smooth muscle cells
Medical sciences Medicine
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