NAD+ metabolism is a key modulator of bacterial respiratory epithelial infections

NAD+ metabolism is a key modulator of bacterial respiratory epithelial infections

Lower respiratory tract infections caused by Streptococcus pneumoniae (Spn) are a leading cause of death globally. Here we investigate the bronchial epithelial cellular response to Spn infection on a transcriptomic, proteomic and metabolic level. We found the NAD+ salvage pathway to be dysregulat...

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Autoren: Klabunde, Björn, Wesener, André, Bertrams, Wilhelm, Beinborn, Isabell, Paczia, Nicole, Surmann, Kristin, Blankenburg, Sascha, Wilhelm, Jochen, Serrania, Javier, Knoops, Kèvin, Elsayed, Eslam M., Laakmann, Katrin, Jung, Anna Lena, Kirschbaum, Andreas, Hammerschmidt, Sven, Alshaar, Belal, Gisch, Nicolas, Abu Mraheil, Mobarak, Völker, Uwe, Vollmeister, Evelyn, Benedikter, Birke J., Schmeck, Bernd,
Format: Artikel
Jezik:angleščina
Izdano: Philipps-Universität Marburg 2024
Teme:
Pathogens
Medizin
Molecular medicine
Bacterial infection
Antimicrobial responses
Medical sciences Medicine
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Publikationen im Open Access gefördert durch die UB

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