Mitochondrial dysfunction in Parkinson’s disease – a key disease hallmark with therapeutic potential

Mitochondrial dysfunction in Parkinson’s disease – a key disease hallmark with therapeutic potential

Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic Parkinson’s disease (PD). However, strategies aimed at ameliorating mitochondrial dysfunction, including antioxidants, antidiabetic drugs, and iron chelators, have failed in disease-modification clinical tri...

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Detalhes bibliográficos
Principais autores: Henrich, Martin T., Oertel, Wolfgang H., Surmeier, D. James, Geibl, Fanni F.
Formato: Artigo
Idioma:inglês
Publicado em: Philipps-Universität Marburg 2024
Assuntos:
MPTP
Neuroprotective therapies
Medizin
Mitochondria
Mitochondrial dysfunction
Parkinson’s disease
Electron transport chain, Antioxidants
Synuclein
Medical sciences Medicine
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