Mitochondrial dysfunction in Parkinson’s disease – a key disease hallmark with therapeutic potential

Mitochondrial dysfunction in Parkinson’s disease – a key disease hallmark with therapeutic potential

Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic Parkinson’s disease (PD). However, strategies aimed at ameliorating mitochondrial dysfunction, including antioxidants, antidiabetic drugs, and iron chelators, have failed in disease-modification clinical tri...

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Autori principali: Henrich, Martin T., Oertel, Wolfgang H., Surmeier, D. James, Geibl, Fanni F.
Natura: Articolo
Lingua:inglese
Pubblicazione: Philipps-Universität Marburg 2024
Soggetti:
MPTP
Neuroprotective therapies
Medizin
Mitochondria
Mitochondrial dysfunction
Parkinson’s disease
Electron transport chain, Antioxidants
Synuclein
Medical sciences Medicine
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