Molecular modeling and phylogenetic analyses highlight the role of amino acid 347 of the N1 subtype neuraminidase in influenza virus host range and interspecies adaptation

Molecular modeling and phylogenetic analyses highlight the role of amino acid 347 of the N1 subtype neuraminidase in influenza virus host range and interspecies adaptation

The N1 neuraminidases (NAs) of avian and pandemic human influenza viruses contain tyrosine and asparagine, respectively, at position 347 on the rim of the catalytic site; the biological significance of this difference is not clear. Here, we used molecular dynamics simulation to model the effects...

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Autoren: Elli, Stefano, Raffaini, Giuseppina, Guerrini, Marco, Kosakovsky Pond, Sergei, Matrosovich, Mikhail
Format: Artikel
Sprache:Englisch
Veröffentlicht: Philipps-Universität Marburg 2023
Schlagworte:
H5N1
neuraminidase
influenza
MD simulation
Medizin
substrate specificity
natural selection
Medical sciences Medicine
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