Trans-ancestry polygenic models for the prediction of LDL blood levels: an analysis of the United Kingdom Biobank and Taiwan Biobank

Trans-ancestry polygenic models for the prediction of LDL blood levels: an analysis of the United Kingdom Biobank and Taiwan Biobank

Polygenic risk score (PRS) predictions often show bias toward the population of available genome-wide association studies (GWASs), which is typically of European ancestry. This study aimed to assess the performance differences of ancestry-specific PRS and test the implementation of multi-ancestry PR...

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Autori principali: Hassanin, Emadeldin, Lee, Ko-Han, Hsieh, Tzung-Chien, Aldisi, Rana, Lee, Yi-Lun, Bobbili, Dheeraj, Krawitz, Peter, May, Patrick, Chen, Chien-Yu, Maj, Carlo
Natura: Articolo
Lingua:inglese
Pubblicazione: Philipps-Universität Marburg 2023
Soggetti:
East Asia
LDL cholesterol
United Kingdom Biobank
Taiwan Biobank
polygenic risk score
Medizin
Medical sciences Medicine
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