Bacterial extracellular vesicles repress the vascular protective factor RNase1 in human lung endothelial cells

Bacterial extracellular vesicles repress the vascular protective factor RNase1 in human lung endothelial cells

Background: Sepsis is one of the leading causes of death worldwide and characterized by blood stream infections associated with a dysregulated host response and endothelial cell (EC) dysfunction. Ribonuclease 1 (RNase1) acts as a protective factor of vascular homeostasis and is known to be repressed...

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Autoren: Laakmann, Katrin, Eckersberg, Jorina Mona, Hapke, Moritz, Wiegand, Marie, Bierwagen, Jeff, Beinborn, Isabell, Preußer, Christian, Pogge von Strandmann, Elke, Heimerl, Thomas, Schmeck, Bernd, Jung, Anna Lena
Format: Artikel
Sprache:Englisch
Veröffentlicht: Philipps-Universität Marburg 2023
Schlagworte:
Inflammation
Sepsis
p38
Ribonuclease 1
TLR4
Polymyxin B
Medizin
OMV
Endothelium
Medical sciences Medicine
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