MAGED2 Depletion Promotes Stress-Induced Autophagy by Impairing the cAMP/PKA Pathway

MAGED2 Depletion Promotes Stress-Induced Autophagy by Impairing the cAMP/PKA Pathway

Melanoma-associated antigen D2 (MAGED2) plays an essential role in activating the cAMP/PKA pathway under hypoxic conditions, which is crucial for stimulating renal salt reabsorption and thus explaining the transient variant of Bartter’s syndrome. The cAMP/PKA pathway is also known to regulate aut...

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Autoren: Nasrah, Sadiq, Radi, Aline, Daberkow, Johanna K., Hummler, Helmut, Weber, Stefanie, Seaayfan, Elie, Kömhoff, Martin
Format: Artikel
Jezik:angleščina
Izdano: Philipps-Universität Marburg 2023
Teme:
G-alpha-S
Bartter’s syndrome
MAGED2
hypoxia nephrogenesis
cellular stress
Medizin
autophagy
cAMP
Medical sciences Medicine
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