Bacterial vesicles block viral replication in macrophages via TLR4‑TRIF‑axis

Bierwagen, Jeff; Wiegand, Marie; Laakmann, Katrin; Danov, Olga; Limburg, Hannah; Herbel, Stefanie Muriel; Heimerl, Thomas; Dorna, Jens; Jonigk, Danny; Preußer, Christian; Bertrams, Wilhelm; Braun, Armin; Sewald, Katherina; Schulte, Leon N.; Bauer, Stefan; Pogge von Strandmann, Elke; Böttcher-Friebertshäuser, Eva; Schmeck, Bernd; Jung, Anna Lena

Bacterial vesicles block viral replication in macrophages via TLR4‑TRIF‑axis

Gram-negative bacteria naturally secrete nano-sized outer membrane vesicles (OMVs), which are important mediators of communication and pathogenesis. OMV uptake by host cells activates TLR signalling via transported PAMPs. As important resident immune cells, alveolar macrophages are located at the ai...

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Autoren:	Bierwagen, Jeff, Wiegand, Marie, Laakmann, Katrin, Danov, Olga, Limburg, Hannah, Herbel, Stefanie Muriel, Heimerl, Thomas, Dorna, Jens, Jonigk, Danny, Preußer, Christian, Bertrams, Wilhelm, Braun, Armin, Sewald, Katherina, Schulte, Leon N., Bauer, Stefan, Pogge von Strandmann, Elke, Böttcher-Friebertshäuser, Eva, Schmeck, Bernd, Jung, Anna Lena
格式:	Artikel
語言:	英语
出版:	Philipps-Universität Marburg 2023
主題:	Antiviral innate immunity Outer membrane vesicles Extracellular vesicles Pneumonia Macrophage, Alveolar epithelial cell Bacterial and viral co-infection Medizin Medical sciences Medicine
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Bacterial vesicles block viral replication in macrophages via TLR4‑TRIF‑axis

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