Complement alternative pathway determines disease susceptibility and severity in antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis

Activation of the alternative pathway (AP) of complement is involved in the pathogenesis of antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV), although the underlying molecular mechanisms are unclear. To gain insight into the role of the AP, common gene variants in CFH/CFHR1-5,...

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Huvudupphovsmän: Lucientes-Continente, Laura, Fernández-Juárez, Gema, Márquez-Tirado, Bárbara, Jímenez-Villegas, Laura, Acevedo, Marcedes, Cavero, Teresa, Sánchez Cámara, Luís, Draibe, Juliana, Anton-Pampols, Paula, Carava-Fontán, Fernando, Praga, Manuel, Villacorta, Javier, Goicoechea de Jorge, Elena
Institutionell upphovsman: Kidney International (Herausgebendes Organ)
Materialtyp: Artikel
Språk:engelska
Publicerad: Philipps-Universität Marburg 2023
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