Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation

Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population with potent suppressive and regulative properties. MDSCs’ strong immunosuppressive potential creates new possibilities to treat chronic inflammation and autoimmune diseases or induce tolerance towards transplantation. Here,...

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Đã lưu trong:
Chi tiết về thư mục
Những tác giả chính: van Geffen, Chiel, Heiss, Constantin, Deißler, Astrid, Kolahian, Saeed
Định dạng: Bài viết
Ngôn ngữ:Tiếng Anh
Được phát hành: Philipps-Universität Marburg 2022
Những chủ đề:
MDSC
immune suppression
pharmacotherapy
immunomodulation
inflammation
Medizin
Medical sciences Medicine
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Miêu tả
Tóm tắt:Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population with potent suppressive and regulative properties. MDSCs’ strong immunosuppressive potential creates new possibilities to treat chronic inflammation and autoimmune diseases or induce tolerance towards transplantation. Here, we summarize and critically discuss different pharmacological approaches which modulate the generation, activation, and recruitment of MDSCs in vitro and in vivo, and their potential role in future immunosuppressive therapy.
Mô tả sách:Gefördert durch den Open-Access-Publikationsfonds der UB Marburg.
DOI:10.3389/fimmu.2022.933847

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