Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson’s disease

Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson’s disease

Parkinson’s disease (PD) is clinically defined by the presence of the cardinal motor symptoms, which are associated with a loss of dopaminergic nigrostriatal neurons in the substantia nigra pars compacta (SNpc). While SNpc neurons serve as the prototypical cell-type to study cellular vulnerability i...

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Autoren: Matschke, Lina A., Komadowski, Marlene A., Stöhr, Annette, Lee, Bolam, Henrich, Martin T., Griesbach, Markus, Rinné, Susanne, Geibl, Fanni F., Chiu, Wei-Hua, Koprich, James B., Brotchie, Jonathan M., Kiper, Aytug K., Dolga, Amalia M., Oertel, Wolfgang H., Decher, Niels
Format: Artikel
Sprache:Englisch
Veröffentlicht: Philipps-Universität Marburg 2022
Schlagworte:
Medizin
Medical sciences Medicine
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Signatur: urn:nbn:de:hebis:04-es2023-00846
Publikationsdatum: 2023-07-13
Quelle: Erstveröffentlichung: Matschke, L.A., Komadowski, M.A., Stöhr, A. et al. Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson’s disease. Sci Rep 12, 3180 (2022). https://doi.org/10.1038/s41598-022-06832-1
Downloads: 15 (2024), 31 (2023)
Lizenz: https://creativecommons.org/licenses/by/4.0
Zugangs-URL: https://archiv.ub.uni-marburg.de/es/2023/0084
https://doi.org/10.1038/s41598-022-06832-1

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