Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson’s disease

Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson’s disease

Parkinson’s disease (PD) is clinically defined by the presence of the cardinal motor symptoms, which are associated with a loss of dopaminergic nigrostriatal neurons in the substantia nigra pars compacta (SNpc). While SNpc neurons serve as the prototypical cell-type to study cellular vulnerability i...

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Auteurs principaux: Matschke, Lina A., Komadowski, Marlene A., Stöhr, Annette, Lee, Bolam, Henrich, Martin T., Griesbach, Markus, Rinné, Susanne, Geibl, Fanni F., Chiu, Wei-Hua, Koprich, James B., Brotchie, Jonathan M., Kiper, Aytug K., Dolga, Amalia M., Oertel, Wolfgang H., Decher, Niels
Format: Article
Langue:anglais
Publié: Philipps-Universität Marburg 2022
Sujets:
Medizin
Medical sciences Medicine
Accès en ligne:Texte intégral en PDF
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