MAGED2 Is Required under Hypoxia for cAMP Signaling by Inhibiting MDM2-Dependent Endocytosis of G-Alpha-S

Seaayfan, Elie; Nasrah, Sadiq; Quell, Lea; Kleim, Maja; Weber, Stefanie; Meyer, Hemmo; Laghmani, Kamel; Kömhoff, Martin

MAGED2 Is Required under Hypoxia for cAMP Signaling by Inhibiting MDM2-Dependent Endocytosis of G-Alpha-S

Mutations in MAGED2 cause transient Bartter syndrome characterized by severe renal salt wasting in fetuses and infants, which leads to massive polyhydramnios causing preterm labor, extreme prematurity and perinatal death. Notably, this condition resolves spontaneously in parallel with developmental...

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Autoren:	Seaayfan, Elie, Nasrah, Sadiq, Quell, Lea, Kleim, Maja, Weber, Stefanie, Meyer, Hemmo, Laghmani, Kamel, Kömhoff, Martin
Formato:	Artigo
Idioma:	inglés
Publicado:	Philipps-Universität Marburg 2022
Schlagworte:	MAGED2 Medizin G-alpha-S MDM2 Bartter hypoxia Medical sciences Medicine
Acceso en liña:	Texto completo PDF
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MAGED2 Is Required under Hypoxia for cAMP Signaling by Inhibiting MDM2-Dependent Endocytosis of G-Alpha-S

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