Lateralization in Hemiparkinsonian Rats Is Affected by either Deep Brain Stimulation or Glutamatergic Neurotransmission in the Inferior Colliculus

Lateralization in Hemiparkinsonian Rats Is Affected by either Deep Brain Stimulation or Glutamatergic Neurotransmission in the Inferior Colliculus

After unilateral lesion of the medial forebrain bundle by 6-OHDA rats exhibit lateralized deficits in spontaneous behavior or apomorphine-induced rotations. We investigated whether such lateralization is attenuated by either deep brain stimulation (DBS) or glutamatergic neurotransmission in the infe...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Melo-Thomas, Liana, Tacken, Lars, Richter, Nicole, Almeida, Davina de, Rapôso, Catarina, Melo, Silvana Regina de, Thomas, Uwe, Bezerra de Paiva, Yara, Medeiros, Priscila, Coimbra, Norberto Cysne, Schwarting, Rainer
Hōputu: Tuhinga
Reo:Ingarihi
I whakaputaina: Philipps-Universität Marburg 2023
Ngā marau:
deep brain stimulation
glutamate
inferior colliculus
medial forebrain bundle; Parkinson’s disease
Psychologie
6-OHDA lesion
Psychology
Urunga tuihono:Kuputuhi katoa PDF
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Whakaahuatanga
Whakarāpopototanga:After unilateral lesion of the medial forebrain bundle by 6-OHDA rats exhibit lateralized deficits in spontaneous behavior or apomorphine-induced rotations. We investigated whether such lateralization is attenuated by either deep brain stimulation (DBS) or glutamatergic neurotransmission in the inferior colliculus (IC) of Wistar rats. Intracollicular DBS did not affect spontaneous lateralization but attenuated apomorphine-induced rotations. Spontaneous lateralization disappeared after either the glutamatergic antagonist MK-801 or the agonist NMDA microinjections into the IC. Apomorphine-induced rotations were potentiated by MK-801 but were not affected by NMDA intracollicular microinjection. After injecting a bidirectional neural tract tracer into the IC, cell bodies and/or axonal fibers were found in the periaqueductal gray matter, superior colliculus, substantia nigra, cuneiform nucleus, and pedunculo-pontine tegmental nucleus, suggesting the involvement of these structures in the motor improvement after IC manipulation. Importantly, the side of the IC microinjection regarding the lesion (ipsilateral or contralateral) is particularly important, and this effect may not involve the neostriatum directly.
Whakaahutanga tūemi:Gefördert durch den Open-Access-Publikationsfonds der UB Marburg.
Whakaahuatanga ōkiko:19 Seiten
DOI:10.1523/ENEURO.0076-22.2022

Ngā tūemi rite