Resultados da pesquisa - Klebe, Gerhard

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  1. 1
    Crystallographic Fragment Screening on the Shigella Type III Secretion System Chaperone IpgC

    Crystallographic Fragment Screening on the Shigella Type III Secretion System Chaperone IpgC Por Gárdonyi, Marina, Hasewinkel, Christian, Wallbaum, Johanna, Wollenhapt, Jan, Weiss, Manfred S., Klebe, Gerhard, Reuter, Klaus, Heine, Andreas

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  2. 2
    Leitstruktursuche mithilfe eines kristallographischen Fragment-Screenings zur Inhibierung des Klasse-II-Chaperons IpgC aus Shigella flexneri

    Leitstruktursuche mithilfe eines kristallographischen Fragment-Screenings zur Inhibierung des Klasse-II-Chaperons IpgC aus Shigella flexneri Por Gárdonyi, Marina

    Publicado em 2021
    Outros Autores: “...Klebe, Gerhard (Prof. Dr.)...”
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  3. 3
    Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase

    Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase Por Sandner, Anna Sophie

    Publicado em 2022
    Outros Autores: “...Klebe, Gerhard (Prof. Dr.)...”
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  4. 4
    Mutational Studies on 17β-HSD14, Serial Synchrotron X-ray Crystallography, Solubility Enhancement using Cyclodextrins and Fragment-Based Drug Discovery Multiple Blocks to Pave the Road of Drug Design

    Mutational Studies on 17β-HSD14, Serial Synchrotron X-ray Crystallography, Solubility Enhancement using Cyclodextrins and Fragment-Based Drug Discovery Multiple Blocks to Pave the... Por Badran, Mohammed

    Publicado em 2021
    Outros Autores: “...Klebe, Gerhard (Prof. Dr.)...”
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  5. 5
    Neue Ansätze zur Entwicklung von Modulatoren der homodimeren tRNA-Guanin-Transglycosylase

    Neue Ansätze zur Entwicklung von Modulatoren der homodimeren tRNA-Guanin-Transglycosylase Por Nguyen, Andreas

    Publicado em 2020
    Outros Autores: “...Klebe, Gerhard (Prof. Dr.)...”
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  6. 6
    Fragment-basierte Leitstruktursuche am Beispiel der Proteinkinase A

    Fragment-basierte Leitstruktursuche am Beispiel der Proteinkinase A Por Oebbeke, Matthias

    Publicado em 2021
    Outros Autores: “...Klebe, Gerhard (Prof. Dr.)...”
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  7. 7
    From Serendipity to the Rational Design of Protein–Protein Interface Modulators Targeting a tRNA-Modifying Enzyme

    From Serendipity to the Rational Design of Protein–Protein Interface Modulators Targeting a tRNA-Modifying Enzyme Por Nguyen, Dzung

    Publicado em 2020
    Outros Autores: “...Klebe, Gerhard (Prof. Dr.)...”
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  8. 8
    Thermodynamic, Kinetic and Crystallographic Investigations of Benzenesulfonamides as Ligands of Human Carbonic Anhydrase II

    Thermodynamic, Kinetic and Crystallographic Investigations of Benzenesulfonamides as Ligands of Human Carbonic Anhydrase II Por Glöckner, Steffen

    Publicado em 2020
    Outros Autores: “...Klebe, Gerhard Prof. Dr....”
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  9. 9
    Do All Roads Really Lead to Rome? Learnings from Comparative Analysis using SPR, NMR, & X-Ray Crystallography to Optimize Fragment Screening in Drug Discovery.

    Do All Roads Really Lead to Rome? Learnings from Comparative Analysis using SPR, NMR, & X-Ray Crystallography to Optimize Fragment Screening in Drug Discovery. Por Hassaan, Engi

    Publicado em 2019
    Outros Autores: “...Klebe, Gerhard (Prof. Dr.)...”
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  10. 10
    Synthese von D-Phe/D-DiPhe-Pro-basierenden Liganden und deren biophysikalischen Charakterisierung zur Selektivitätsstudie von Thrombin und Trypsin sowie ein synthetischer Beitrag zur Darstellung von Inhibitoren der Aldose-Reduktase und Carboanhydrase II

    Synthese von D-Phe/D-DiPhe-Pro-basierenden Liganden und deren biophysikalischen Charakterisierung zur Selektivitätsstudie von Thrombin und Trypsin sowie ein synthetischer Beitrag z... Por Ngo, Trong Khang

    Publicado em 2020
    Outros Autores: “...Klebe, Gerhard (Prof. Dr.)...”
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  11. 11
    Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery

    Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery Por Petrick, Joy Kristin

    Publicado em 2019
    Outros Autores: “...Klebe, Gerhard (Prof. Dr.)...”
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  12. 12
    Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery

    Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery Por Münzker Lena

    Publicado em 2019
    Outros Autores: “...Klebe, Gerhard (Prof. Dr.)...”
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  13. 13
    The Power of Fragments: FBLD approach to investigate protein structures

    The Power of Fragments: FBLD approach to investigate protein structures Por Magari, Francesca

    Publicado em 2020
    Outros Autores: “...Klebe, Gerhard (Prof. Dr.)...”
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  14. 14
    Identifizierung, Charakterisierung und Untersuchungen der Struktur-Wirkungs-Beziehung sowie des Mode of Action eines neuen antimikrobiellen Peptids aus Hirudo verbana

    Identifizierung, Charakterisierung und Untersuchungen der Struktur-Wirkungs-Beziehung sowie des Mode of Action eines neuen antimikrobiellen Peptids aus Hirudo verbana Por Müller, Daniela

    Publicado em 2019
    Outros Autores: “...Klebe, Gerhard (Prof. Dr. rer. nat.)...”
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  15. 15
    Expanding the Toolbox for Computational Analysis in Rational Drug Discovery: Using Biomolecular Solvation to Predict Thermodynamic, Kinetic and Structural Properties of Protein-Ligand Complexes

    Expanding the Toolbox for Computational Analysis in Rational Drug Discovery: Using Biomolecular Solvation to Predict Thermodynamic, Kinetic and Structural Properties of Protein-Lig... Por Hüfner, Tobias

    Publicado em 2019
    Outros Autores: “...Klebe, Gerhard (Prof. Dr.)...”
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  16. 16
    Inhibitor Synthesis and Biophysical Characterization of Protein–Ligand–Solvent Interactions An Analysis of the Thermodynamics and Kinetics of Ligand Binding to Thermolysin

    Inhibitor Synthesis and Biophysical Characterization of Protein–Ligand–Solvent Interactions An Analysis of the Thermodynamics and Kinetics of Ligand Binding to Thermolysin Por Cramer, Jonathan

    Publicado em 2017
    Outros Autores: “...Klebe, Gerhard (Prof. Dr.)...”
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  17. 17
    Characterisation and differentiation of kinase binding pockets in PKA and PIM1 by small molecule fragments using protein crystallography

    Characterisation and differentiation of kinase binding pockets in PKA and PIM1 by small molecule fragments using protein crystallography Por Siefker, Christof

    Publicado em 2018
    Outros Autores: “...Klebe, Gerhard (Prof. Dr.)...”
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  18. 18
    Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques

    Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques Por Bertoletti, Nicole

    Publicado em 2017
    Outros Autores: “...Klebe, Gerhard (Prof. Dr.)...”
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  19. 19
    Beyond Affinity: Drug-Kinase Interaction Put under the Microscope

    Beyond Affinity: Drug-Kinase Interaction Put under the Microscope Por Wienen-Schmidt, Barbara

    Publicado em 2017
    Outros Autores: “...Klebe, Gerhard (Prof.)...”
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  20. 20
    Proteindynamik - Flexibilität in Zielproteinen des strukturbasierten Wirkstoffdesigns

    Proteindynamik - Flexibilität in Zielproteinen des strukturbasierten Wirkstoffdesigns Por Terwesten, Felix

    Publicado em 2017
    Outros Autores: “...Klebe, Gerhard (Prof. Dr.)...”
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