Search Results - Klebe, Gerhard

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  1. 1
    Crystallographic Fragment Screening on the Shigella Type III Secretion System Chaperone IpgC

    Crystallographic Fragment Screening on the Shigella Type III Secretion System Chaperone IpgC by Gárdonyi, Marina, Hasewinkel, Christian, Wallbaum, Johanna, Wollenhapt, Jan, Weiss, Manfred S., Klebe, Gerhard, Reuter, Klaus, Heine, Andreas

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  2. 2
    Leitstruktursuche mithilfe eines kristallographischen Fragment-Screenings zur Inhibierung des Klasse-II-Chaperons IpgC aus Shigella flexneri

    Leitstruktursuche mithilfe eines kristallographischen Fragment-Screenings zur Inhibierung des Klasse-II-Chaperons IpgC aus Shigella flexneri by Gárdonyi, Marina

    Published 2021
    Contributors: “…Klebe, Gerhard (Prof. Dr.)…”
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  3. 3
    Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase

    Optimization of the Drug Design Process by Ligand Preorganization and Occupancy of Transient Binding Pockets Based on the Model Proteins Thrombin and Aldose Reductase by Sandner, Anna Sophie

    Published 2022
    Contributors: “…Klebe, Gerhard (Prof. Dr.)…”
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  4. 4
    Mutational Studies on 17β-HSD14, Serial Synchrotron X-ray Crystallography, Solubility Enhancement using Cyclodextrins and Fragment-Based Drug Discovery Multiple Blocks to Pave the Road of Drug Design

    Mutational Studies on 17β-HSD14, Serial Synchrotron X-ray Crystallography, Solubility Enhancement using Cyclodextrins and Fragment-Based Drug Discovery Multiple Blocks to Pave the... by Badran, Mohammed

    Published 2021
    Contributors: “…Klebe, Gerhard (Prof. Dr.)…”
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  5. 5
    Neue Ansätze zur Entwicklung von Modulatoren der homodimeren tRNA-Guanin-Transglycosylase

    Neue Ansätze zur Entwicklung von Modulatoren der homodimeren tRNA-Guanin-Transglycosylase by Nguyen, Andreas

    Published 2020
    Contributors: “…Klebe, Gerhard (Prof. Dr.)…”
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  6. 6
    Fragment-basierte Leitstruktursuche am Beispiel der Proteinkinase A

    Fragment-basierte Leitstruktursuche am Beispiel der Proteinkinase A by Oebbeke, Matthias

    Published 2021
    Contributors: “…Klebe, Gerhard (Prof. Dr.)…”
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  7. 7
    From Serendipity to the Rational Design of Protein–Protein Interface Modulators Targeting a tRNA-Modifying Enzyme

    From Serendipity to the Rational Design of Protein–Protein Interface Modulators Targeting a tRNA-Modifying Enzyme by Nguyen, Dzung

    Published 2020
    Contributors: “…Klebe, Gerhard (Prof. Dr.)…”
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  8. 8
    Thermodynamic, Kinetic and Crystallographic Investigations of Benzenesulfonamides as Ligands of Human Carbonic Anhydrase II

    Thermodynamic, Kinetic and Crystallographic Investigations of Benzenesulfonamides as Ligands of Human Carbonic Anhydrase II by Glöckner, Steffen

    Published 2020
    Contributors: “…Klebe, Gerhard Prof. Dr.…”
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  9. 9
    Do All Roads Really Lead to Rome? Learnings from Comparative Analysis using SPR, NMR, & X-Ray Crystallography to Optimize Fragment Screening in Drug Discovery.

    Do All Roads Really Lead to Rome? Learnings from Comparative Analysis using SPR, NMR, & X-Ray Crystallography to Optimize Fragment Screening in Drug Discovery. by Hassaan, Engi

    Published 2019
    Contributors: “…Klebe, Gerhard (Prof. Dr.)…”
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  10. 10
    Synthese von D-Phe/D-DiPhe-Pro-basierenden Liganden und deren biophysikalischen Charakterisierung zur Selektivitätsstudie von Thrombin und Trypsin sowie ein synthetischer Beitrag zur Darstellung von Inhibitoren der Aldose-Reduktase und Carboanhydrase II

    Synthese von D-Phe/D-DiPhe-Pro-basierenden Liganden und deren biophysikalischen Charakterisierung zur Selektivitätsstudie von Thrombin und Trypsin sowie ein synthetischer Beitrag z... by Ngo, Trong Khang

    Published 2020
    Contributors: “…Klebe, Gerhard (Prof. Dr.)…”
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  11. 11
    Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery

    Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery by Petrick, Joy Kristin

    Published 2019
    Contributors: “…Klebe, Gerhard (Prof. Dr.)…”
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  12. 12
    Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery

    Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery by Münzker Lena

    Published 2019
    Contributors: “…Klebe, Gerhard (Prof. Dr.)…”
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  13. 13
    The Power of Fragments: FBLD approach to investigate protein structures

    The Power of Fragments: FBLD approach to investigate protein structures by Magari, Francesca

    Published 2020
    Contributors: “…Klebe, Gerhard (Prof. Dr.)…”
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  14. 14
    Identifizierung, Charakterisierung und Untersuchungen der Struktur-Wirkungs-Beziehung sowie des Mode of Action eines neuen antimikrobiellen Peptids aus Hirudo verbana

    Identifizierung, Charakterisierung und Untersuchungen der Struktur-Wirkungs-Beziehung sowie des Mode of Action eines neuen antimikrobiellen Peptids aus Hirudo verbana by Müller, Daniela

    Published 2019
    Contributors: “…Klebe, Gerhard (Prof. Dr. rer. nat.)…”
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  15. 15
    Expanding the Toolbox for Computational Analysis in Rational Drug Discovery: Using Biomolecular Solvation to Predict Thermodynamic, Kinetic and Structural Properties of Protein-Ligand Complexes

    Expanding the Toolbox for Computational Analysis in Rational Drug Discovery: Using Biomolecular Solvation to Predict Thermodynamic, Kinetic and Structural Properties of Protein-Lig... by Hüfner, Tobias

    Published 2019
    Contributors: “…Klebe, Gerhard (Prof. Dr.)…”
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  16. 16
    Inhibitor Synthesis and Biophysical Characterization of Protein–Ligand–Solvent Interactions An Analysis of the Thermodynamics and Kinetics of Ligand Binding to Thermolysin

    Inhibitor Synthesis and Biophysical Characterization of Protein–Ligand–Solvent Interactions An Analysis of the Thermodynamics and Kinetics of Ligand Binding to Thermolysin by Cramer, Jonathan

    Published 2017
    Contributors: “…Klebe, Gerhard (Prof. Dr.)…”
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  17. 17
    Characterisation and differentiation of kinase binding pockets in PKA and PIM1 by small molecule fragments using protein crystallography

    Characterisation and differentiation of kinase binding pockets in PKA and PIM1 by small molecule fragments using protein crystallography by Siefker, Christof

    Published 2018
    Contributors: “…Klebe, Gerhard (Prof. Dr.)…”
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  18. 18
    Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques

    Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques by Bertoletti, Nicole

    Published 2017
    Contributors: “…Klebe, Gerhard (Prof. Dr.)…”
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  19. 19
    Beyond Affinity: Drug-Kinase Interaction Put under the Microscope

    Beyond Affinity: Drug-Kinase Interaction Put under the Microscope by Wienen-Schmidt, Barbara

    Published 2017
    Contributors: “…Klebe, Gerhard (Prof.)…”
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  20. 20
    Proteindynamik - Flexibilität in Zielproteinen des strukturbasierten Wirkstoffdesigns

    Proteindynamik - Flexibilität in Zielproteinen des strukturbasierten Wirkstoffdesigns by Terwesten, Felix

    Published 2017
    Contributors: “…Klebe, Gerhard (Prof. Dr.)…”
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