Dokument
| Titel: | Investigations on the biosynthesis of secondary metabolites and biosynthetic enzymes from Aspergillus species |
| Autor: | Zheng, Liujuan |
| Weitere Beteiligte: | Li, Shu-Ming (Prof. Dr.) |
| Veröffentlicht: | 2021 |
| URI: | https://archiv.ub.uni-marburg.de/diss/z2021/0219 |
| DOI: | https://doi.org/10.17192/z2021.0219 |
| URN: | urn:nbn:de:hebis:04-z2021-02191 |
| DDC: | 570 Biowissenschaften, Biologie |
| Titel (trans.): | Untersuchungen zur Biosynthese von Sekundärmetaboliten und zu biosynthetischen Enzymen aus Aspergillus-Arten |
| Publikationsdatum: | 2021-06-08 |
| Lizenz: | https://creativecommons.org/licenses/by-nc-sa/4.0 |
| Schlagwörter: |
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| biosynthesis, nichtribosomalen Peptidsynthasen, Sekundärmetabolite, Biosynthese, Pilzen, polyketides, Polyketidsyntasen, Fungi, nonribosomal peptides, secondary metabolites |
Summary:
In this thesis, BGCs for secondary metabolites from A. ustus have been investigated via multiple approaches. The identified PKS-containing utt BGC and two similar NRPS-containing opa and opa2 BGCs from the same fungus A. ustus demonstrated clearly the large fungal potential for natural product production and new enzyme discovery. In addition, site-directed mutagenesis for a fungal PT led to the functional switching with enhanced conversion yields, indicating that site-directed mutagenesis is an effective tool to increase the structural diversity of natural products.
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