Publikationsserver der Universitätsbibliothek Marburg
Titel:Immunologisch basierte Wirkmechanismen der O3/O2-PP-Tumortherapie
Autor:Rossmann, Annette
Weitere Beteiligte: Bette, Michael (PD Dr.)
Veröffentlicht:2014
URI:https://archiv.ub.uni-marburg.de/diss/z2014/0713
URN: urn:nbn:de:hebis:04-z2014-07134
DOI: https://doi.org/10.17192/z2014.0713
DDC: Medizin
Titel (trans.):Immunologically based mechanisms of action of the O3/O2-PP-tumor therapy
Publikationsdatum:2014-11-18
Lizenz:https://rightsstatements.org/vocab/InC-NC/1.0/

Dokument

Schlagwörter:
head neck squamous cell carcinoma, Papillomaviren, Oxidativer Stress, immunosurveillance, VX2 tumor, Immunreaktion, VX2-Tumor,, Tumorimmunologie, papilloma virus, oxidative stress, Plattenepithelcarcinom, Ozon, Ozone, Hals-Kopf-Karzinome

Zusammenfassung:
Plattenepithelkarzinome des Kopf- und Halsbereiches (Head and Neck Squamous Cell Carcinomas (HNSCCs)) stellen weltweit die 6. häufigste Tumorerkrankung dar. Als etabliertes Tiermodell für HNSCC dient das aurikuläre VX2-Tumormodell des Weißen Neuseelandkaninchens (NZW). VX2-Tumoren ähneln HNSCCs in ihrer Morphologie, einem lymphogenen Metastasierungsverhalten und zeichnen sich, analog zu HPV-induzierten HNSCCs, durch eine virale Ätiologie aus. In dieser Arbeit wurde das VX2-Tumormodell genutzt, um den zugrundeliegenden Mechanismus der antitumorigenen Wirkung einer intraperitonealen Applikation von oxidativem Stress, in Form einer O3/O2-Pneumoperitoneum (O3/O2-PP) Behandlung, zu charakterisieren. Solide aurikuläre VX2-Tumoren wurden beim NZW-Kaninchen induziert. Bei Erreichen einer definierten Tumorgröße wurde die O3/O2-PP-Behandlung durchgeführt und die sich daraufhin regressiv bzw. progressiv entwickelnden Tumoren chirurgisch abgetragen. Die O3/O2-PP-Behandlung resultierte, verglichen mit einer Kontroll- (Sham-) Behandlung, in einer signifikant gesteigerten Regressionsrate der aurikulären VX2-Tumoren. Eine signifikant erhöhte Anzahl tumorinfiltrierender T-Lymphozyten (TILs) im Gewebe remittierender Tumoren konnte immunhistochemisch ermittelt werden. Molekularbiologische Analysen von immunologisch relevanten Faktoren zeigten eine Zunahme in den Expressionsspiegeln von Genen aus der Gruppe der Pattern-Recognition Receptors, inflammatorischen Mediatoren sowie Molekülen, die essentiell für die Antigenpräsentation und T-Zellaktivierung sind. Anhand von adoptiven Zelltransferexperimenten konnte der funktionelle Nachweis erbracht werden, dass sich in Tieren, die durch die O3/O2-PP-Behandlung den Tumor erfolgreich bekämpfen konnten, Gedächtniszellen gegen den VX2-Tumor entwickelten. Diese Zellen wurden durch den Transfer von PBL auf tumorkranke Empfängertiere übertragen und führten auch in diesen zu einer Tumorregression. Reimplantationsexperimente in geheilten Tieren bestätigten den Erwerb einer Tumorresistenz und die damit verbundene Präsenz von Gedächtniszellen gegen den VX2-Tumor. Untersuchungen zur Genexpression von epidermalen Wachstumsfaktor-Rezeptoren ergaben eine signifikant geringere Expression von EGFR, ErbB2 und ErbB3 in regressiven Tumoren. In situ Hybridisierungsanalysen, zur Lokalisation der Wachstumsfaktor-Rezeptoren, zeigten eine verstärkte Expression von EGFR in der Tumorfront und eine homogene Verteilung der ErbB2 und ErbB3 im gesamten Tumorgewebe. Die Daten untermauern die Annahme einer immunvermittelten Remission des VX2-Tumors durch intraperitoneal applizierten oxidativen Stress (O3/O2-PP) unter Hochregulation antitumorigener Immunantworten und Reduktion von Wachstumsfaktor-Rezeptoren im Tumorgewebe. Die intraperitoneale Applikation von oxidativem Stress könnte somit eine potentielle Krebsimmuntherapie im Sinne aktueller Therapieansätze darstellen, die eine Aktivierung isolierter TILs durch in vitro-Stimulation nicht mehr erforderlich macht. Die Analyse der O3/O2-induzierten intraperitonealen Wirkmechanismen könnte damit zur Entwicklung definierter Tumortherapien beitragen.

Bibliographie / References

  1. Lee Y, Ma J, Lyu H, Huang J, Kim A,Liu B (2014). "Role of erbB3 receptors in cancer therapeutic resistance." Acta Biochim Biophys Sin (Shanghai) 46(3): 190-8.
  2. Nishikawa H,Sakaguchi S (2010). "Regulatory T cells in tumor immunity." Int J Cancer 127(4): 759-67.
  3. Laurent A, Nicco C, Chereau C, Goulvestre C, Alexandre J, Alves A, Levy E, Goldwasser F, Panis Y, Soubrane O, Weill B,Batteux F (2005). "Controlling tumor growth by modulating endogenous production of reactive oxygen species." Cancer Res 65(3): 948-56.
  4. Lee-Hoeflich ST, Crocker L, Yao E, Pham T, Munroe X, Hoeflich KP, Sliwkowski MX,Stern HM (2008). "A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy." Cancer Res 68(14): 5878-87.
  5. Naito Y, Saito K, Shiiba K, Ohuchi A, Saigenji K, Nagura H,Ohtani H (1998). "CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer." Cancer Res 58(16): 3491-4.
  6. Bergmann C, Strauss L, Wang Y, Szczepanski MJ, Lang S, Johnson JT,Whiteside TL (2008). "T regulatory type 1 cells in squamous cell carcinoma of the head and neck: mechanisms of suppression and expansion in advanced disease." Clin Cancer Res 14(12): 3706-15.
  7. "Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members." Clin Cancer Res 5(12): 4164- 74.
  8. Yen HR, Harris TJ, Wada S, Grosso JF, Getnet D, Goldberg MV, Liang KL, Bruno TC, Pyle KJ, Chan SL, Anders RA, Trimble CL, Adler AJ, Lin TY, Pardoll DM, Huang CT,Drake CG (2009). "Tc17 CD8 T cells: functional plasticity and subset diversity." J Immunol 183(11): 7161-8.
  9. de Heer P, Gosens MJ, de Bruin EC, Dekker-Ensink NG, Putter H, Marijnen CA, van den Brule AJ, van Krieken JH, Rutten HJ, Kuppen PJ,van de Velde CJ (2007). "Cyclooxygenase 2 expression in rectal cancer is of prognostic significance in patients receiving preoperative radiotherapy." Clin Cancer Res 13(10): 2955-60.
  10. Trimboli AJ, Fukino K, de Bruin A, Wei G, Shen L, Tanner SM, Creasap N, Rosol TJ, Robinson ML, Eng C, Ostrowski MC,Leone G (2008). "Direct evidence for epithelial-mesenchymal transitions in breast cancer." Cancer Res 68(3): 937-45.
  11. Petersen RP, Campa MJ, Sperlazza J, Conlon D, Joshi MB, Harpole DH, Jr.,Patz EF, Jr. (2006). "Tumor infiltrating Foxp3+ regulatory T-cells are associated with recurrence in pathologic stage I NSCLC patients." Cancer 107(12): 2866-72.
  12. Ye J, Su X, Hsueh EC, Zhang Y, Koenig JM, Hoft DF,Peng G (2011). "Human tumor-infiltrating Th17 cells have the capacity to differentiate into IFN-gamma+ and FOXP3+ T cells with potent suppressive function." Eur J Immunol 41(4): 936-51.
  13. Luheshi N, Davies G, Poon E, Wiggins K, McCourt M,Legg J (2014). "Th1 cytokines are more effective than Th2 cytokines at licensing anti-tumour functions in CD40-activated human macrophages in vitro." Eur J Immunol 44(1): 162-72.
  14. Lang F, Linlin M, Ye T,Yuhai Z (2012). "Alterations of dendritic cell subsets and TH1/TH2 cytokines in the peripheral circulation of patients with superficial transitional cell carcinoma of the bladder." J Clin Lab Anal 26(5): 365-71.
  15. Al-Dalain SM, Martinez G, Candelario-Jalil E, Menendez S, Re L, Giuliani A,Leon OS (2001). "Ozone treatment reduces markers of oxidative and endothelial damage in an experimental diabetes model in rats." Pharmacol Res 44(5): 391-6.
  16. Camus M,Galon J (2010). "Memory T-cell responses and survival in human cancer: remember to stay alive." Adv Exp Med Biol 684: 166-77.
  17. Bellovin DI, Das B,Felsher DW (2013). "Tumor dormancy, oncogene addiction, cellular senescence, and self-renewal programs." Adv Exp Med Biol 734: 91-107.
  18. Burnet F (1971). "Immunological Surveillance in Neoplasia." 7(1): 3-25.
  19. Afzal S, Jensen SA, Sorensen JB, Henriksen T, Weimann A,Poulsen HE (2012). "Oxidative damage to guanine nucleosides following combination chemotherapy with 5-fluorouracil and oxaliplatin." Cancer Chemother Pharmacol 69(2): 301-7.
  20. Otto W, Denzinger S, Wieland WF,Hartmann A (2012). "First analysis of immune cell infiltration in stage pT1 urothelial bladder carcinoma: CD3 positivity as a prognostic marker for cancer- specific survival." World J Urol 30(6): 875-7.
  21. "Investigation of Th1/Th2 cytokine profiles in patients with laryngo-pharyngeal, HPV-positive cancers." Eur Arch Otorhinolaryngol 270(2): 711-8.
  22. Richter P, Bohmer FD, Hindermann W, Borsi L, Hyckel P, Schleier P, Katenkamp D, Kosmehl H,Berndt A (2005). "Analysis of activated EGFR signalling pathways and their relation to laminin-5 gamma2 chain expression in oral squamous cell carcinoma (OSCC)." Histochem Cell Biol 124(2): 151-60.
  23. Rathinam R,Alahari SK (2010). "Important role of integrins in the cancer biology." Cancer Metastasis Rev 29(1): 223-37.
  24. Mlecnik B, Bindea G, Pages F,Galon J (2011). "Tumor immunosurveillance in human cancers." Cancer Metastasis Rev 30(1): 5-12.
  25. Madej P, Plewka A, Madej JA, Nowak M, Plewka D, Franik G,Golka D (2007). "Ozonotherapy in an induced septic shock. I. Effect of ozonotherapy on rat organs in evaluation of free radical reactions and selected enzymatic systems." Inflammation 30(1-2): 52-8.
  26. Tasdemir C, Tasdemir S, Vardi N, Ates B, Onal Y, Erdogan S, Yucel A, Aglamis E, Yakupogullari Y, Altintas R,Karaman A (2013). "Evaluation of the effects of ozone therapy on Escherichia coli- induced cytitis in rat." Ir J Med Sci 182(4): 557-63.
  27. Harris RC, Chung E,Coffey RJ (2003). "EGF receptor ligands." Exp Cell Res 284(1): 2-13.
  28. Bocci VA (2006). "Scientific and medical aspects of ozone therapy. State of the art." Arch Med Res 37(4): 425-35.
  29. Hou N, Zhang X, Zhao L, Zhao X, Li Z, Song T,Huang C (2013). "A novel chronic stress-induced shift in the Th1 to Th2 response promotes colon cancer growth." Biochem Biophys Res Commun 439(4): 471-6.
  30. Meric JB, Rottey S, Olaussen K, Soria JC, Khayat D, Rixe O,Spano JP (2006). "Cyclooxygenase-2 as a target for anticancer drug development." Crit Rev Oncol Hematol 59(1): 51-64.
  31. Cohen RB (2014). "Current challenges and clinical investigations of epidermal growth factor receptor (EGFR)-and ErbB family-targeted agents in the treatment of head and neck squamous cell carcinoma (HNSCC)." Cancer Treat Rev 40(4): 567-77.
  32. Gul H, Uysal B, Cakir E, Yaman H, Macit E, Yildirim AO, Eyi YE, Kaldirim U, Oztas E, Akgul EO, Cayci T, Ozler M, Topal T, Oter S, Korkmaz A, Toygar M,Demirbag S (2012). "The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury." Environ Toxicol Pharmacol 34(1): 81-6.
  33. Uysal B, Demirbag S, Poyrazoglu Y, Cayci T, Yesildaglar N, Guven A, Surer I,Korkmaz A (2012). "Medical ozone therapy decreases postoperative uterine adhesion formation in rats." Arch Gynecol Obstet 286(5): 1201-7.
  34. Gaur P, Singh AK, Shukla NK,Das SN (2014). "Inter-relation of Th1, Th2, Th17 and Treg cytokines in oral cancer patients and their clinical significance." Hum Immunol 75(4): 330-7.
  35. Ettl T, Stiegler C, Zeitler K, Agaimy A, Zenk J, Reichert TE, Gosau M, Kuhnel T, Brockhoff G,Schwarz S (2012). "EGFR, HER2, survivin, and loss of pSTAT3 characterize high-grade malignancy in salivary gland cancer with impact on prognosis." Hum Pathol 43(6): 921-31.
  36. Chung CH, Zhang Q, Hammond EM, Trotti AM, 3rd, Wang H, Spencer S, Zhang HZ, Cooper J, Jordan R, Rotman MH,Ang KK (2011). "Integrating epidermal growth factor receptor assay with clinical parameters improves risk classification for relapse and survival in head-and-neck squamous cell carcinoma." Int J Radiat Oncol Biol Phys 81(2): 331-8.
  37. Chen DS,Mellman I (2013). "Oncology meets immunology: the cancer-immunity cycle." Immunity 39(1): 1-10.
  38. Almaz ME,Sonmez IS (2013). "Ozone therapy in the management and prevention of caries." J Formos Med Assoc.
  39. Guven A, Gundogdu G, Vurucu S, Uysal B, Oztas E, Ozturk H,Korkmaz A (2009). "Medical ozone therapy reduces oxidative stress and intestinal damage in an experimental model of necrotizing enterocolitis in neonatal rats." J Pediatr Surg 44(9): 1730-5.
  40. "Protective effect of intraperitoneal ozone application in experimental ovarian ischemia/reperfusion injury." J Pediatr Surg 47(9): 1730-4.
  41. Martin F, Apetoh L,Ghiringhelli F (2012). "Controversies on the role of Th17 in cancer: a TGF-beta- dependent immunosuppressive activity?" Trends Mol Med 18(12): 742-9.
  42. Yamaguchi T,Sakaguchi S (2006). "Regulatory T cells in immune surveillance and treatment of cancer." Semin Cancer Biol 16(2): 115-23.
  43. Linggi B,Carpenter G (2006). "ErbB receptors: new insights on mechanisms and biology." Trends Cell Biol 16(12): 649-56.
  44. Larini A,Bocci V (2005). "Effects of ozone on isolated peripheral blood mononuclear cells." Toxicol In Vitro 19(1): 55-61.
  45. Chu F, Feng Q, Qian Y, Zhang C, Fang Z,Shen G (2011). "ERBB2 gene amplification in oral squamous cell malignancies: a correlation with tumor progression and gene expression." Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112(1): 90-5.
  46. Carpenter G (2003). "ErbB-4: mechanism of action and biology." Exp Cell Res 284(1): 66-77.
  47. Soltes L, Mendichi R, Kogan G, Schiller J, Stankovska M,Arnhold J (2006). "Degradative action of reactive oxygen species on hyaluronan." Biomacromolecules 7(3): 659-68.
  48. Zou W,Restifo NP (2010). "T(H)17 cells in tumour immunity and immunotherapy." Nat Rev Immunol 10(4): 248-56.
  49. Masopust D,Schenkel JM (2013). "The integration of T cell migration, differentiation and function." Nat Rev Immunol 13(5): 309-20.
  50. Chen I,Dubnau D (2004). "DNA uptake during bacterial transformation." Nat Rev Microbiol 2(3): 241-9.
  51. Pradere JP, Dapito DH,Schwabe RF (2013). "The Yin and Yang of Toll-like receptors in cancer." Oncogene.
  52. Mutsaers SE (2002). "Mesothelial cells: their structure, function and role in serosal repair." Respirology 7(3): 171-91.
  53. van Es RJ, Dullens HF, van der Bilt A, Koole R,Slootweg PJ (2000). "Evaluation of the VX2 rabbit auricle carcinoma as a model for head and neck cancer in humans." J Craniomaxillofac Surg 28(5): 300-7.
  54. Gillessen S, Naumov YN, Nieuwenhuis EE, Exley MA, Lee FS, Mach N, Luster AD, Blumberg RS, Taniguchi M, Balk SP, Strominger JL, Dranoff G,Wilson SB (2003). "CD1d-restricted T cells regulate dendritic cell function and antitumor immunity in a granulocyte-macrophage colony- stimulating factor-dependent fashion." Proc Natl Acad Sci U S A 100(15): 8874-9.
  55. Finn OJ (2012). "Immuno-oncology: understanding the function and dysfunction of the immune system in cancer." Ann Oncol 23 Suppl 8: viii6-9.
  56. Yamawaki H, Hirohata S, Miyoshi T, Takahashi K, Ogawa H, Shinohata R, Demircan K, Kusachi S, Yamamoto K,Ninomiya Y (2009). "Hyaluronan receptors involved in cytokine induction in monocytes." Glycobiology 19(1): 83-92.
  57. Ocana A, Vera-Badillo F, Seruga B, Templeton A, Pandiella A,Amir E (2013). "HER3 overexpression and survival in solid tumors: a meta-analysis." J Natl Cancer Inst 105(4): 266-73.
  58. Leone P, Shin EC, Perosa F, Vacca A, Dammacco F,Racanelli V (2013). "MHC class I antigen processing and presenting machinery: organization, function, and defects in tumor cells." J Natl Cancer Inst 105(16): 1172-87.
  59. Corpet F (1988). "Multiple sequence alignment with hierarchical clustering." Nucleic Acids Res 16(22): 10881-90.
  60. Hu J, Budgeon LR, Cladel NM, Culp TD, Balogh KK,Christensen ND (2007). "Detection of L1, infectious virions and anti-L1 antibody in domestic rabbits infected with cottontail rabbit papillomavirus." J Gen Virol 88(Pt 12): 3286-93.
  61. McCarthy JT, Pelle E, Dong K, Brahmbhatt K, Yarosh D,Pernodet N (2013). "Effects of ozone in normal human epidermal keratinocytes." Exp Dermatol 22(5): 360-1.
  62. Higashiyama S, Iwabuki H, Morimoto C, Hieda M, Inoue H,Matsushita N (2008). "Membrane-anchored growth factors, the epidermal growth factor family: beyond receptor ligands." Cancer Sci 99(2): 214-20.
  63. Leon Fernandez OS, Ajamieh HH, Berlanga J, Menendez S, Viebahn-Hansler R, Re L,Carmona AM (2008). "Ozone oxidative preconditioning is mediated by A1 adenosine receptors in a rat model of liver ischemia/ reperfusion." Transpl Int 21(1): 39-48.
  64. Silva SD, Cunha IW, Younes RN, Soares FA, Kowalski LP,Graner E (2010). "ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas." Oral Dis 16(8): 774-80.
  65. Juuti A, Louhimo J, Nordling S, Ristimaki A,Haglund C (2006). "Cyclooxygenase-2 expression correlates with poor prognosis in pancreatic cancer." J Clin Pathol 59(4): 382-6.
  66. Halonen JI, Lanki T, Tiittanen P, Niemi JV, Loh M,Pekkanen J (2010). "Ozone and cause-specific cardiorespiratory morbidity and mortality." J Epidemiol Community Health 64(9): 814-20.
  67. Ahmed N, Maines-Bandiera S, Quinn MA, Unger WG, Dedhar S,Auersperg N (2006). "Molecular pathways regulating EGF-induced epithelio-mesenchymal transition in human ovarian surface epithelium." Am J Physiol Cell Physiol 290(6): C1532-42.
  68. Zamora ZB, Borrego A, Lopez OY, Delgado R, Gonzalez R, Menendez S, Hernandez F,Schulz S (2005). "Effects of ozone oxidative preconditioning on TNF-alpha release and antioxidant- prooxidant intracellular balance in mice during endotoxic shock." Mediators Inflamm 2005(1): 16-22.
  69. Hallett MA, Venmar KT,Fingleton B (2012). "Cytokine stimulation of epithelial cancer cells: the similar and divergent functions of IL-4 and IL-13." Cancer Res 72(24): 6338-43.
  70. Yee C (2013). "Adoptive T-cell therapy for cancer: boutique therapy or treatment modality?" Clin Cancer Res 19(17): 4550-2.
  71. Kantengwa S, Jornot L, Devenoges C,Nicod LP (2003). "Superoxide anions induce the maturation of human dendritic cells." Am J Respir Crit Care Med 167(3): 431-7.
  72. Bhola NE, Balko JM, Dugger TC, Kuba MG, Sanchez V, Sanders M, Stanford J, Cook RS,Arteaga CL (2013). "TGF-beta inhibition enhances chemotherapy action against triple-negative breast cancer." J Clin Invest 123(3): 1348-58.
  73. Goerner M, Seiwert TY,Sudhoff H (2010). "Molecular targeted therapies in head and neck cancer--an update of recent developments." Head Neck Oncol 2: 8.
  74. Iida N, Nakamoto Y, Baba T, Kakinoki K, Li YY, Wu Y, Matsushima K, Kaneko S,Mukaida N (2008). "Tumor cell apoptosis induces tumor-specific immunity in a CC chemokine receptor 1-and 5- dependent manner in mice." J Leukoc Biol 84(4): 1001-10.
  75. Bates GJ, Fox SB, Han C, Leek RD, Garcia JF, Harris AL,Banham AH (2006). "Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse." J Clin Oncol 24(34): 5373-80.
  76. Tarhini AA, Kirkwood JM, Gooding WE, Cai C,Agarwala SS (2007). "Durable complete responses with high-dose bolus interleukin-2 in patients with metastatic melanoma who have experienced progression after biochemotherapy." J Clin Oncol 25(25): 3802-7.
  77. Wang XY, Zuo D, Sarkar D,Fisher PB (2011). "Blockade of cytotoxic T-lymphocyte antigen-4 as a new therapeutic approach for advanced melanoma." Expert Opin Pharmacother 12(17): 2695-706.
  78. Wakatsuki K, Sho M, Yamato I, Takayama T, Matsumoto S, Tanaka T, Migita K, Ito M, Hotta K,Nakajima Y (2013). "Clinical impact of tumor-infiltrating CD45RO(+) memory T cells on human gastric cancer." Oncol Rep 29(5): 1756-62.
  79. Li Z, Potts EN, Piantadosi CA, Foster WM,Hollingsworth JW (2010). "Hyaluronan fragments contribute to the ozone-primed immune response to lipopolysaccharide." J Immunol 185(11): 6891-8.
  80. Yu Y, Cho HI, Wang D, Kaosaard K, Anasetti C, Celis E,Yu XZ (2013). "Adoptive transfer of Tc1 or Tc17 cells elicits antitumor immunity against established melanoma through distinct mechanisms." J Immunol 190(4): 1873-81.
  81. "Protective role of the inflammatory CCR2/CCL2 chemokine pathway through recruitment of type 1 cytotoxic gammadelta T lymphocytes to tumor beds." J Immunol 190(12): 6673-80.
  82. "Dendritic cells capture killed tumor cells and present their antigens to elicit tumor-specific immune responses." J Immunol 165(7): 3797-803.
  83. Baratelli F, Lin Y, Zhu L, Yang SC, Heuze-Vourc'h N, Zeng G, Reckamp K, Dohadwala M, Sharma S,Dubinett SM (2005). "Prostaglandin E2 induces FOXP3 gene expression and T regulatory cell function in human CD4+ T cells." J Immunol 175(3): 1483-90.
  84. Salaun B, Coste I, Rissoan MC, Lebecque SJ,Renno T (2006). "TLR3 can directly trigger apoptosis in human cancer cells." J Immunol 176(8): 4894-901.
  85. Scheibner KA, Lutz MA, Boodoo S, Fenton MJ, Powell JD,Horton MR (2006). "Hyaluronan fragments act as an endogenous danger signal by engaging TLR2." J Immunol 177(2): 1272-81.
  86. Cheng YS,Xu F (2012). "Anticancer function of polyinosinic-polycytidylic acid." Cancer Biol Ther 10(12): 1219-23.
  87. Campo MS, Graham SV, Cortese MS, Ashrafi GH, Araibi EH, Dornan ES, Miners K, Nunes C,Man S (2010). "HPV-16 E5 down-regulates expression of surface HLA class I and reduces recognition by CD8 T cells." Virology 407(1): 137-42.
  88. Marchetti B, Ashrafi GH, Dornan ES, Araibi EH, Ellis SA,Campo MS (2006). "The E5 protein of BPV-4 interacts with the heavy chain of MHC class I and irreversibly retains the MHC complex in the Golgi apparatus." Oncogene 25(15): 2254-63.
  89. Ashrafi GH, Haghshenas MR, Marchetti B, O'Brien PM,Campo MS (2005). "E5 protein of human papillomavirus type 16 selectively downregulates surface HLA class I." Int J Cancer 113(2): 276-83.
  90. Tschopp J,Schroder K (2010). "NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?" Nat Rev Immunol 10(3): 210-5.
  91. "Neutrophil gelatinase-associated lipocalin (NGAL) an early-screening biomarker for ovarian cancer: NGAL is associated with epidermal growth factor-induced epithelio-mesenchymal transition." Int J Cancer 120(11): 2426-34.
  92. "Lymphogenic metastatic spread of auricular VX2 carcinoma in New Zealand white rabbits." Anticancer Res 22(6A): 3273-9.
  93. Chen R, Alvero AB, Silasi DA, Steffensen KD,Mor G (2008). "Cancers take their Toll--the function and regulation of Toll-like receptors in cancer cells." Oncogene 27(2): 225-33.
  94. Goutagny N, Estornes Y, Hasan U, Lebecque S,Caux C (2012). "Targeting pattern recognition receptors in cancer immunotherapy." Target Oncol 7(1): 29-54.
  95. Ackland ML, Newgreen DF, Fridman M, Waltham MC, Arvanitis A, Minichiello J, Price JT,Thompson EW (2003). "Epidermal growth factor-induced epithelio-mesenchymal transition in human breast carcinoma cells." Lab Invest 83(3): 435-48.
  96. Takeuchi O,Akira S (2010). "Pattern recognition receptors and inflammation." Cell 140(6): 805-20.
  97. Yung S, Li FK,Chan TM (2006). "Peritoneal mesothelial cell culture and biology." Perit Dial Int 26(2): 162-73.
  98. Ellyard JI, Simson L,Parish CR (2007). "Th2-mediated anti-tumour immunity: friend or foe?" Tissue Antigens 70(1): 1-11.
  99. Novick D, Kim S, Kaplanski G,Dinarello CA (2013). "Interleukin-18, more than a Th1 cytokine." Semin Immunol 25(6): 439-48.
  100. Corsini E, Galbiati V, Nikitovic D,Tsatsakis AM (2013). "Role of oxidative stress in chemical allergens induced skin cells activation." Food Chem Toxicol 61: 74-81.
  101. Agostoni E,Zocchi L (2007). "Pleural liquid and its exchanges." Respir Physiol Neurobiol 159(3): 311- 23.
  102. Halbauer K, Prskalo K, Jankovic B, Tarle Z, Panduric V,Kalenic S (2013). "Efficacy of ozone on microorganisms in the tooth root canal." Coll Antropol 37(1): 101-7.
  103. Hanahan D,Weinberg RA (2011). "Hallmarks of cancer: the next generation." Cell 144(5): 646-74.
  104. Kalyankrishna S,Grandis JR (2006). "Epidermal growth factor receptor biology in head and neck cancer." J Clin Oncol 24(17): 2666-72.
  105. Nishimura T, Iwakabe K, Sekimoto M, Ohmi Y, Yahata T, Nakui M, Sato T, Habu S, Tashiro H, Sato M,Ohta A (1999). "Distinct role of antigen-specific T helper type 1 (Th1) and Th2 cells in tumor eradication in vivo." J Exp Med 190(5): 617-27.
  106. Adams JC (1981). "Heavy metal intensification of DAB-based HRP reaction product." J Histochem Cytochem 29(6): 775.
  107. Lakshmi Narendra B, Eshvendar Reddy K, Shantikumar S,Ramakrishna S (2013). "Immune system: a double-edged sword in cancer." Inflamm Res 62(9): 823-34.
  108. Wiegand S, Wiemers C, Murthum T, Zimmermann AP, Bette M, Mandic R,Werner JA (2013). "Risk of lymph node metastases after en bloc cold steel, en bloc laser-, and piecemeal laser surgical resection of auricular VX2 carcinoma." Lasers Med Sci 28(4): 1137-41.
  109. Cao C, Chen Y, Masood R, Sinha UK,Kobielak A (2012). "alpha-Catulin marks the invasion front of squamous cell carcinoma and is important for tumor cell metastasis." Mol Cancer Res 10(7): 892-903.
  110. Cook NR, Lee IM, Zhang SM, Moorthy MV,Buring JE (2013). "Alternate-day, low-dose aspirin and cancer risk: long-term observational follow-up of a randomized trial." Ann Intern Med 159(2): 77-85.
  111. Tepper RI, Coffman RL,Leder P (1992). "An eosinophil-dependent mechanism for the antitumor effect of interleukin-4." Science 257(5069): 548-51.
  112. McHeyzer-Williams LJ,McHeyzer-Williams MG (2005). "Antigen-specific memory B cell development." Annu Rev Immunol 23: 487-513.
  113. Chalmers SA, Eidelman AS, Ewer JC, Ricca JM, Serrano A, Tucker KC, Vail CM,Kurt RA (2013). "A role for HMGB1, HSP60 and Myd88 in growth of murine mammary carcinoma in vitro." Cell Immunol 282(2): 136-45.
  114. Tougeron D, Sha D, Manthravadi S,Sinicrope FA (2014). "Aspirin and colorectal cancer: back to the future." Clin Cancer Res 20(5): 1087-94.
  115. Kidd JG,Rous P (1940). "A Transplantable Rabbit Carcinoma Originating in a Virus-Induced Papilloma and Containing the Virus in Masked or Altered Form." J Exp Med 71(6): 813-38.
  116. Candolfi M, Curtin JF, Yagiz K, Assi H, Wibowo MK, Alzadeh GE, Foulad D, Muhammad AK, Salehi S, Keech N, Puntel M, Liu C, Sanderson NR, Kroeger KM, Dunn R, Martins G, Lowenstein PR,Castro MG (2011). "B cells are critical to T-cell-mediated antitumor immunity induced by a combined immune-stimulatory/conditionally cytotoxic therapy for glioblastoma." Neoplasia 13(10): 947-60.
  117. Nathan C,Cunningham-Bussel A (2013). "Beyond oxidative stress: an immunologist's guide to reactive oxygen species." Nat Rev Immunol 13(5): 349-61.
  118. Sengupta N, MacFie TS, MacDonald TT, Pennington D,Silver AR (2010). "Cancer immunoediting and "spontaneous" tumor regression." Pathol Res Pract 206(1): 1-8.
  119. Schreiber RD, Old LJ,Smyth MJ (2011). "Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion." Science 331(6024): 1565-70.
  120. Gupta GP,Massague J (2006). "Cancer metastasis: building a framework." Cell 127(4): 679-95.
  121. Shibuya TY, Nugyen N, McLaren CE, Li KT, Wei WZ, Kim S, Yoo GH, Rogowski A, Ensley J,Sakr W (2002). "Clinical significance of poor CD3 response in head and neck cancer." Clin Cancer Res 8(3): 745-51.
  122. Sentani K, Matsuda M, Oue N, Uraoka N, Naito Y, Sakamoto N,Yasui W (2013). "Clinicopathological significance of MMP-7, laminin gamma2 and EGFR expression at the invasive front of gastric carcinoma." Gastric Cancer.
  123. Ghosh N, Chaki R, Mandal V,Mandal SC (2010). "COX-2 as a target for cancer chemotherapy." Pharmacol Rep 62(2): 233-44.
  124. "Cyclooxygenase-2 expression is a novel prognostic factor in malignant mesothelioma." Clin Cancer Res 8(6): 1857-62.
  125. Dranoff G (2004). "Cytokines in cancer pathogenesis and cancer therapy." Nat Rev Cancer 4(1): 11- 22.
  126. Sharma A, Rajappa M, Satyam A,Sharma M (2009). "Cytokines (TH1 and TH2) in patients with advanced cervical cancer undergoing neoadjuvant chemoradiation: correlation with treatment response." Int J Gynecol Cancer 19(7): 1269-75.
  127. Werner M, Chott A, Fabiano A,Battifora H (2000). "Effect of formalin tissue fixation and processing on immunohistochemistry." Am J Surg Pathol 24(7): 1016-9.
  128. Huth KC, Jakob FM, Saugel B, Cappello C, Paschos E, Hollweck R, Hickel R,Brand K (2006). "Effect of ozone on oral cells compared with established antimicrobials." Eur J Oral Sci 114(5): 435-40.
  129. Pages F, Berger A, Camus M, Sanchez-Cabo F, Costes A, Molidor R, Mlecnik B, Kirilovsky A, Nilsson M, Damotte D, Meatchi T, Bruneval P, Cugnenc PH, Trajanoski Z, Fridman WH,Galon J (2005). "Effector memory T cells, early metastasis, and survival in colorectal cancer." N Engl J Med 353(25): 2654-66.
  130. Citri A,Yarden Y (2006). "EGF-ERBB signalling: towards the systems level." Nat Rev Mol Cell Biol 7(7): 505-16.
  131. Ono Y, Nakanishi Y, Gotoh M, Sakamoto M,Hirohashi S (2002). "Epidermal growth factor receptor gene amplification is correlated with laminin-5 gamma2 chain expression in oral squamous cell carcinoma cell lines." Cancer Lett 175(2): 197-204.
  132. Staruschenko A, Palygin O, Ilatovskaya DV,Pavlov TS (2013). "Epidermal growth factors in the kidney and relationship to hypertension." Am J Physiol Renal Physiol 305(1): F12-20.
  133. Hynes NE,Lane HA (2005). "ERBB receptors and cancer: the complexity of targeted inhibitors." Nat Rev Cancer 5(5): 341-54.
  134. Holbro T,Hynes NE (2004). "ErbB receptors: directing key signaling networks throughout life." Annu Rev Pharmacol Toxicol 44: 195-217.
  135. Rous P, Kidd JG,Smith WE (1952). "Experiments on the cause of the rabbit carcinomas derived from virus-induced papillomas. II. Loss by the Vx2 carcinoma of the power to immunize hosts against the papilloma virus." J Exp Med 96(2): 159-74.
  136. Crittenden M, Gough M, Harrington K, Olivier K, Thompson J,Vile RG (2003). "Expression of inflammatory chemokines combined with local tumor destruction enhances tumor regression and long-term immunity." Cancer Res 63(17): 5505-12.
  137. Mandic R, Dunne AA, Eikelkamp N, Ramaswamy A, Schulz S, Teymoortash A, Sesterhenn A, Moll R,Werner JA (2002). "Expression of MMP-3, MMP-13, TIMP-2 and TIMP-3 in the VX2 carcinoma of the New Zealand white rabbit." Anticancer Res 22(6A): 3281-4.
  138. Holtmeier W,Kabelitz D (2005). "gammadelta T cells link innate and adaptive immune responses." Chem Immunol Allergy 86: 151-83.
  139. Ye ZJ, Zhou Q, Gu YY, Qin SM, Ma WL, Xin JB, Tao XN,Shi HZ (2010). "Generation and differentiation of IL-17-producing CD4+ T cells in malignant pleural effusion." J Immunol 185(10): 6348-54.
  140. Sedlacek AL, Gerber SA, Randall TD, van Rooijen N, Frelinger JG,Lord EM (2013). "Generation of a dual-functioning antitumor immune response in the peritoneal cavity." Am J Pathol 183(4): 1318-28.
  141. Yung S,Chan T (2007). "Glycosaminoglycans and proteoglycans: overlooked entities?" Perit Dial Int. 27(Suppl 2): 104-9.
  142. Chung CH,Gillison ML (2009). "Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications." Clin Cancer Res 15(22): 6758-62.
  143. Kreimer AR, Clifford GM, Boyle P,Franceschi S (2005). "Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review." Cancer Epidemiol Biomarkers Prev 14(2): 467-75.
  144. Ang KK, Berkey BA, Tu X, Zhang HZ, Katz R, Hammond EH, Fu KK,Milas L (2002). "Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma." Cancer Res 62(24): 7350-6.
  145. Chung CH, Ely K, McGavran L, Varella-Garcia M, Parker J, Parker N, Jarrett C, Carter J, Murphy BA, Netterville J, Burkey BB, Sinard R, Cmelak A, Levy S, Yarbrough WG, Slebos RJ,Hirsch FR (2006). "Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas." J Clin Oncol 24(25): 4170-6.
  146. Shope RE,Hurst EW (1933). "Infectious Papillomatosis of Rabbits: With a Note on the Histopathology." J Exp Med 58(5): 607-24.
  147. Zitvogel L, Kepp O, Galluzzi L,Kroemer G (2012). "Inflammasomes in carcinogenesis and anticancer immune responses." Nat Immunol 13(4): 343-51.
  148. Gajewski TF, Schreiber H,Fu YX (2013). "Innate and adaptive immune cells in the tumor microenvironment." Nat Immunol 14(10): 1014-22.
  149. Kortylewski M, Komyod W, Kauffmann ME, Bosserhoff A, Heinrich PC,Behrmann I (2004). "Interferon- gamma-mediated growth regulation of melanoma cells: involvement of STAT1-dependent and STAT1-independent signals." J Invest Dermatol 122(2): 414-22.
  150. Santin AD, Hermonat PL, Ravaggi A, Bellone S, Pecorelli S, Roman JJ, Parham GP,Cannon MJ (2000). "Interleukin-10 increases Th1 cytokine production and cytotoxic potential in human papillomavirus-specific CD8(+) cytotoxic T lymphocytes." J Virol 74(10): 4729-37.
  151. "Intratumoral regulatory T cells upregulate immunosuppressive molecules in head and neck cancer patients." Br J Cancer 109(10): 2629-35.
  152. "Intravenous chemotherapy with cisplatin for regional lymph node metastases of auricular VX2 carcinoma." Anticancer Res 24(3a): 1785-9.
  153. Kruser TJ,Wheeler DL (2010). "Mechanisms of resistance to HER family targeting antibodies." Exp Cell Res 316(7): 1083-100.
  154. Shimotsuma M, Shields JW, Simpson-Morgan MW, Sakuyama A, Shirasu M, Hagiwara A,Takahashi T (1993). "Morpho-physiological function and role of omental milky spots as omentum- associated lymphoid tissue (OALT) in the peritoneal cavity." Lymphology 26(2): 90-101.
  155. Vesely MD, Kershaw MH, Schreiber RD,Smyth MJ (2011). "Natural innate and adaptive immunity to cancer." Annu Rev Immunol 29: 235-71.
  156. Christofori G (2006). "New signals from the invasive front." Nature 441(7092): 444-50.
  157. Brand TM, Iida M, Luthar N, Starr MM, Huppert EJ,Wheeler DL (2013). "Nuclear EGFR as a molecular target in cancer." Radiother Oncol 108(3): 370-7.
  158. Vaillant JD, Fraga A, Diaz MT, Mallok A, Viebahn-Hansler R, Fahmy Z, Barbera A, Delgado L, Menendez S,Fernandez OS (2013). "Ozone oxidative postconditioning ameliorates joint damage and decreases pro-inflammatory cytokine levels and oxidative stress in PG/PS- induced arthritis in rats." Eur J Pharmacol 714(1-3): 318-24.
  159. Fernández Iglesias A, González Núñez L, Calunga Fernández J, Rodríguez Salgueiro S,Santos Febles E (2011). "Ozone postconditioning in renal ischaemia-reperfusion model. Functional and morphological evidences." Nefrologia 31(4): 464-70.
  160. Sweet F, Kao MS, Lee SC, Hagar WL,Sweet WE (1980). "Ozone selectively inhibits growth of human cancer cells." Science 209(4459): 931-3.
  161. Morris JC, Tan AR, Olencki TE, Shapiro GI, Dezube BJ, Reiss M, Hsu FJ, Berzofsky JA,Lawrence DP (2014). "Phase I study of GC1008 (fresolimumab): a human anti-transforming growth factor- beta (TGFbeta) monoclonal antibody in patients with advanced malignant melanoma or renal cell carcinoma." PLoS One 9(3): e90353.
  162. Hedayat M, Takeda K,Rezaei N (2012). "Prophylactic and therapeutic implications of toll-like receptor ligands." Med Res Rev 32(2): 294-325.
  163. Ishii Y, Yang H, Sakamoto T, Nomura A, Hasegawa S, Hirata F,Bassett DJ (1997). "Rat alveolar macrophage cytokine production and regulation of neutrophil recruitment following acute ozone exposure." Toxicol Appl Pharmacol 147(2): 214-23.
  164. Lanca T,Silva-Santos B (2013). "Recruitment of gammadelta T lymphocytes to tumors: A new role for the pleiotropic chemokine CCL2." Oncoimmunology 2(8): e25461.
  165. Zafirova B, Wensveen FM, Gulin M,Polic B (2011). "Regulation of immune cell function and differentiation by the NKG2D receptor." Cell Mol Life Sci 68(21): 3519-29.
  166. de Rezende LC, Silva IV, Rangel LB,Guimaraes MC (2010). "Regulatory T cell as a target for cancer therapy." Arch Immunol Ther Exp (Warsz) 58(3): 179-90.
  167. Shilpa Reddy A, Reddy N, Dinapadu S, Reddy M,Pasari S (2013). "Role of ozone therapy in minimal intervention dentistry and endodontics -a review." J Int Oral Health 5(3): 102-8.
  168. Basith S, Manavalan B, Yoo TH, Kim SG,Choi S (2012). "Roles of toll-like receptors in cancer: a double-edged sword for defense and offense." Arch Pharm Res 35(8): 1297-316.
  169. Zigler M, Shir A,Levitzki A (2013). "Targeted cancer immunotherapy." Curr Opin Pharmacol 13(4): 504- 10.
  170. Byrne WL, Mills KH, Lederer JA,O'Sullivan GC (2011). "Targeting regulatory T cells in cancer." Cancer Res 71(22): 6915-20.
  171. Ji Y,Zhang W (2010). "Th17 cells: positive or negative role in tumor?" Cancer Immunol Immunother 59(7): 979-87.
  172. Sapundzhiev N, Dunne AA, Ramaswamy A,Werner JA (2005). "The auricular VX2 carcinoma: feasibility of complete tumor resection." Anticancer Res 25(6B): 4209-14.
  173. Pryor WA, Squadrito GL,Friedman M (1995). "The cascade mechanism to explain ozone toxicity: the role of lipid ozonation products." Free Radic Biol Med 19(6): 935-41.
  174. Martin-Orozco N, Muranski P, Chung Y, Yang XO, Yamazaki T, Lu S, Hwu P, Restifo NP, Overwijk WW,Dong C (2009). "T helper 17 cells promote cytotoxic T cell activation in tumor immunity." Immunity 31(5): 787-98.
  175. Aguilera A LJ, Gónzalez-Mateo G, Selgas R, López-Cabrera M (2013). The mesothelial to mesenchymal transition a pathogenic and therapeutic key for peritoneal membrane failure. The Latest in Peritoneal Dialysis. A. P. A.
  176. Rous P,Beard JW (1935). "The Progression To Carcinoma Of Virus-Induced Rabbit Papillomas (Shope)." J Exp Med 62(4): 523-48.
  177. Kong CS, Narasimhan B, Cao H, Kwok S, Erickson JP, Koong A, Pourmand N,Le QT (2009). "The relationship between human papillomavirus status and other molecular prognostic markers in head and neck squamous cell carcinomas." Int J Radiat Oncol Biol Phys 74(2): 553-61.
  178. van Es RJ, Franssen O, Dullens HF, Bernsen MR, Bosman F, Hennink WE,Slootweg PJ (1999). "The VX2 carcinoma in the rabbit auricle as an experimental model for intra-arterial embolization of head and neck squamous cell carcinoma with dextran microspheres." Lab Anim 33(2): 175- 84.
  179. Fang H, Ang B, Xu X, Huang X, Wu Y, Sun Y, Wang W, Li N, Cao X,Wan T (2014). "TLR4 is essential for dendritic cell activation and anti-tumor T-cell response enhancement by DAMPs released from chemically stressed cancer cells." Cell Mol Immunol 11(2): 150-9.
  180. Sharma S, Stolina M, Yang SC, Baratelli F, Lin JF, Atianzar K, Luo J, Zhu L, Lin Y, Huang M, Dohadwala M, Batra RK,Dubinett SM (2003). "Tumor cyclooxygenase 2-dependent suppression of dendritic cell function." Clin Cancer Res 9(3): 961-8.
  181. Sharma S, Yang SC, Zhu L, Reckamp K, Gardner B, Baratelli F, Huang M, Batra RK,Dubinett SM (2005). "Tumor cyclooxygenase-2/prostaglandin E2-dependent promotion of FOXP3 expression and CD4+ CD25+ T regulatory cell activities in lung cancer." Cancer Res 65(12): 5211-20.
  182. Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce-Pages C, Tosolini M, Camus M, Berger A, Wind P, Zinzindohoue F, Bruneval P, Cugnenc PH, Trajanoski Z, Fridman WH,Pages F (2006). "Type, density, and location of immune cells within human colorectal tumors predict clinical outcome." Science 313(5795): 1960-4.
  183. Sheu BC, Lin RH, Lien HC, Ho HN, Hsu SM,Huang SC (2001). "Predominant Th2/Tc2 polarity of tumor-infiltrating lymphocytes in human cervical cancer." J Immunol 167(5): 2972-8.
  184. Cai G, Kastelein RA,Hunter CA (1999). "IL-10 enhances NK cell proliferation, cytotoxicity and production of IFN-gamma when combined with IL-18." Eur J Immunol 29(9): 2658-65.
  185. Schulz S, Haussler U, Mandic R, Heverhagen JT, Neubauer A, Dunne AA, Werner JA, Weihe E,Bette M (2008). "Treatment with ozone/oxygen-pneumoperitoneum results in complete remission of rabbit squamous cell carcinomas." Int J Cancer 122(10): 2360-7.
  186. Bose P, Brockton NT,Dort JC (2013). "Head and neck cancer: from anatomy to biology." Int J Cancer 133(9): 2013-23.
  187. Mitsudomi T,Yatabe Y (2010). "Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer." Febs J 277(2): 301-8.
  188. Neparidze N,Dhodapkar MV (2009). "Harnessing CD1d-restricted T cells toward antitumor immunity in humans." Ann N Y Acad Sci 1174: 61-7.
  189. Eccles SA (2011). "The epidermal growth factor receptor/Erb-B/HER family in normal and malignant breast biology." Int J Dev Biol 55(7-9): 685-96.
  190. Rogers SJ, Harrington KJ, Rhys-Evans P, P OC,Eccles SA (2005). "Biological significance of c-erbB family oncogenes in head and neck cancer." Cancer Metastasis Rev 24(1): 47-69.
  191. Lang S, Tiwari S, Andratschke M, Loehr I, Lauffer L, Bergmann C, Mack B, Lebeau A, Moosmann A, Whiteside TL,Zeidler R (2007). "Immune restoration in head and neck cancer patients after in vivo COX-2 inhibition." Cancer Immunol Immunother 56(10): 1645-52.
  192. Nunez S, Saez JJ, Fernandez D, Flores-Santibanez F, Alvarez K, Tejon G, Ruiz P, Maldonado P, Hidalgo Y, Manriquez V, Bono MR, Rosemblatt M,Sauma D (2013). "T helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 cells to the tumour." Immunology 139(1): 61-71.
  193. Wen X, Rao P, Carreno LJ, Kim S, Lawrenczyk A, Porcelli SA, Cresswell P,Yuan W (2013). "Human CD1d knock-in mouse model demonstrates potent antitumor potential of human CD1d- restricted invariant natural killer T cells." Proc Natl Acad Sci U S A 110(8): 2963-8.
  194. "Prognostic impact of tumour-infiltrating Th2 and regulatory T cells in classical Hodgkin lymphoma." Hematol Oncol 27(1): 31-9.
  195. Foglieni C, Fulgenzi A, Belloni D, Sciorati C, Ferrero E,Ferrero ME (2011). "Ozonated autohemotherapy: protection of kidneys from ischemia in rats subjected to unilateral nephrectomy." BMC Nephrol 12: 61.
  196. Rodriguez T, Mendez R, Del Campo A, Jimenez P, Aptsiauri N, Garrido F,Ruiz-Cabello F (2007). "Distinct mechanisms of loss of IFN-gamma mediated HLA class I inducibility in two melanoma cell lines." BMC Cancer 7: 34.
  197. Feller L, Wood NH, Khammissa RA,Lemmer J (2010). "Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1: human papillomavirus-mediated carcinogenesis." Head Face Med 6: 14.
  198. Chen WF,Zlotnik A (1991). "IL-10: a novel cytotoxic T cell differentiation factor." J Immunol 147(2): 528-34.
  199. Termeer CC, Hennies J, Voith U, Ahrens T, Weiss JM, Prehm P,Simon JC (2000). "Oligosaccharides of hyaluronan are potent activators of dendritic cells." J Immunol 165(4): 1863-70.
  200. Li Q, Teitz-Tennenbaum S, Donald EJ, Li M,Chang AE (2009). "In vivo sensitized and in vitro activated B cells mediate tumor regression in cancer adoptive immunotherapy." J Immunol 183(5): 3195-203.
  201. Katoh K, Nakanishi Y, Akimoto S, Yoshimura K, Takagi M, Sakamoto M,Hirohashi S (2002). "Correlation between laminin-5 gamma2 chain expression and epidermal growth factor receptor expression and its clinicopathological significance in squamous cell carcinoma of the tongue." Oncology 62(4): 318-26.
  202. Schulz S, Rodriguez ZZ, Mutters R, Menendez S,Bette M (2003). "Repetitive pneumoperitoneum with ozonized oxygen as a preventive in lethal polymicrobial sepsis in rats." Eur Surg Res 35(1): 26-34.
  203. Makala LH, Suzuki N,Nagasawa H (2002). "Peyer's patches: organized lymphoid structures for the induction of mucosal immune responses in the intestine." Pathobiology 70(2): 55-68.
  204. "Differential molecular and anatomical basis for B cell migration into the peritoneal cavity and omental milky spots." J Immunol 180(4): 2196-203.
  205. Sagai M,Bocci V (2011). "Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress?" Med Gas Res 1: 29.
  206. Li FK, Davenport A, Robson RL, Loetscher P, Rothlein R, Williams JD,Topley N (1998). "Leukocyte migration across human peritoneal mesothelial cells is dependent on directed chemokine secretion and ICAM-1 expression." Kidney Int 54(6): 2170-83.
  207. Baselga J,Swain SM (2009). "Novel anticancer targets: revisiting ERBB2 and discovering ERBB3." Nat Rev Cancer 9(7): 463-75.
  208. Pages F, Galon J, Dieu-Nosjean MC, Tartour E, Sautes-Fridman C,Fridman WH (2010). "Immune infiltration in human tumors: a prognostic factor that should not be ignored." Oncogene 29(8): 1093-102.
  209. Kalos M,June CH (2013). "Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology." Immunity 39(1): 49-60.
  210. Ciocca DR,Calderwood SK (2005). "Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications." Cell Stress Chaperones 10(2): 86-103.
  211. Gattinoni L, Powell DJ, Jr., Rosenberg SA,Restifo NP (2006). "Adoptive immunotherapy for cancer: building on success." Nat Rev Immunol 6(5): 383-93.
  212. Maker AV, Phan GQ, Attia P, Yang JC, Sherry RM, Topalian SL, Kammula US, Royal RE, Haworth LR, Levy C, Kleiner D, Mavroukakis SA, Yellin M,Rosenberg SA (2005). "Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study." Ann Surg Oncol 12(12): 1005-16.
  213. Yang L, Yamagata N, Yadav R, Brandon S, Courtney RL, Morrow JD, Shyr Y, Boothby M, Joyce S, Carbone DP,Breyer RM (2003). "Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor." J Clin Invest 111(5): 727-35.
  214. Gabrielson EW, Yu XY,Spannhake EW (1994). "Comparison of the toxic effects of hydrogen peroxide and ozone on cultured human bronchial epithelial cells." Environ Health Perspect 102(11): 972-4.
  215. Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q,Dong C (2005). "A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17." Nat Immunol 6(11): 1133-41.
  216. "Prevention of renal injury after induction of ozone tolerance in rats submitted to warm ischaemia." Mediators Inflamm 8(1): 37-41.
  217. Zhang H, Berezov A, Wang Q, Zhang G, Drebin J, Murali R,Greene MI (2007). "ErbB receptors: from oncogenes to targeted cancer therapies." J Clin Invest 117(8): 2051-8.
  218. Manzanares D, Monzon ME, Savani RC,Salathe M (2007). "Apical oxidative hyaluronan degradation stimulates airway ciliary beating via RHAMM and RON." Am J Respir Cell Mol Biol 37(2): 160- 8.
  219. Muckle DS,Dickson JA (1971). "The selective inhibitory effect of hyperthermia on the metabolism and growth of malignant cells." Br J Cancer 25(4): 771-8.
  220. Termeer C, Benedix F, Sleeman J, Fieber C, Voith U, Ahrens T, Miyake K, Freudenberg M, Galanos C,Simon JC (2002). "Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4." J Exp Med 195(1): 99-111.
  221. Kim R, Emi M,Tanabe K (2007). "Cancer immunoediting from immune surveillance to immune escape." Immunology 121(1): 1-14.
  222. Nedergaard BS, Ladekarl M, Thomsen HF, Nyengaard JR,Nielsen K (2007). "Low density of CD3+, CD4+ and CD8+ cells is associated with increased risk of relapse in squamous cell cervical cancer." Br J Cancer 97(8): 1135-8.
  223. Hobohm U (2005). "Fever therapy revisited." Br J Cancer 92(3): 421-5.
  224. Georges E, Breitburd F, Jibard N,Orth G (1985). "Two Shope papillomavirus-associated VX2 carcinoma cell lines with different levels of keratinocyte differentiation and transplantability." J Virol 55(1): 246-50.
  225. Rosenberg SA, Restifo NP, Yang JC, Morgan RA,Dudley ME (2008). "Adoptive cell transfer: a clinical path to effective cancer immunotherapy." Nat Rev Cancer 8(4): 299-308.
  226. Thomas L (1982). "On Immunosurveillance in Human Cancer." The Yale Journal of Biology and Medicine 55: 329-333.
  227. Lee KC, Moon WK, Chung JW, Choi SH, Cho N, Cha JH, Lee EH, Kim SM, Kim HS, Han MH,Chang KH (2007). "Assessment of lymph node metastases by contrast-enhanced MR imaging in a head and neck cancer model." Korean J Radiol 8(1): 9-14.
  228. Wilson KJ, Gilmore JL, Foley J, Lemmon MA,Riese DJ, 2nd (2009). "Functional selectivity of EGF family peptide growth factors: implications for cancer." Pharmacol Ther 122(1): 1-8.
  229. Garantziotis S, Li Z, Potts EN, Kimata K, Zhuo L, Morgan DL, Savani RC, Noble PW, Foster WM, Schwartz DA,Hollingsworth JW (2009). "Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice." J Biol Chem 284(17): 11309-17.
  230. Kreuter KA, El-Abbadi N, Shbeeb A, Tseng L, Mahon SB, Narula N, Burney T, Colt H,Brenner M (2008). "Development of a rabbit pleural cancer model by using VX2 tumors." Comp Med 58(3): 287-93.
  231. Kryczek I, Wei S, Szeliga W, Vatan L,Zou W (2009b). "Endogenous IL-17 contributes to reduced tumor growth and metastasis." Blood 114(2): 357-9.
  232. Besch R, Poeck H, Hohenauer T, Senft D, Hacker G, Berking C, Hornung V, Endres S, Ruzicka T, Rothenfusser S,Hartmann G (2009). "Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells." J Clin Invest 119(8): 2399-411.
  233. Kryczek I, Banerjee M, Cheng P, Vatan L, Szeliga W, Wei S, Huang E, Finlayson E, Simeone D, Welling TH, Chang A, Coukos G, Liu R,Zou W (2009a). "Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments." Blood 114(6): 1141-9.
  234. Rydberg C, Mansson A, Uddman R, Riesbeck K,Cardell LO (2009). "Toll-like receptor agonists induce inflammation and cell death in a model of head and neck squamous cell carcinomas." Immunology 128(1 Suppl): e600-11.
  235. Kono H,Rock KL (2008). "How dying cells alert the immune system to danger." Nat Rev Immunol 8(4): 279-89.
  236. Khatri SB, Holguin FC, Ryan PB, Mannino D, Erzurum SC,Teague WG (2009). "Association of ambient ozone exposure with airway inflammation and allergy in adults with asthma." J Asthma 46(8): 777-85.
  237. Tormo D, Checinska A, Alonso-Curbelo D, Perez-Guijarro E, Canon E, Riveiro-Falkenbach E, Calvo TG, Larribere L, Megias D, Mulero F, Piris MA, Dash R, Barral PM, Rodriguez-Peralto JL, Ortiz-Romero P, Tuting T, Fisher PB,Soengas MS (2009). "Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells." Cancer Cell 16(2): 103-14.
  238. Garantziotis S, Li Z, Potts EN, Lindsey JY, Stober VP, Polosukhin VV, Blackwell TS, Schwartz DA, Foster WM,Hollingsworth JW (2010). "TLR4 is necessary for hyaluronan-mediated airway hyperresponsiveness after ozone inhalation." Am J Respir Crit Care Med 181(7): 666-75.
  239. Adams S (2009). "Toll-like receptor agonists in cancer therapy." Immunotherapy 1(6): 949-64.
  240. Sorensen EW, Gerber SA, Sedlacek AL, Rybalko VY, Chan WM,Lord EM (2009). "Omental immune aggregates and tumor metastasis within the peritoneal cavity." Immunol Res 45(2-3): 185-94.
  241. Miura S, Kawana K, Schust DJ, Fujii T, Yokoyama T, Iwasawa Y, Nagamatsu T, Adachi K, Tomio A, Tomio K, Kojima S, Yasugi T, Kozuma S,Taketani Y (2010). "CD1d, a sentinel molecule bridging innate and adaptive immunity, is downregulated by the human papillomavirus (HPV) E5 protein: a possible mechanism for immune evasion by HPV." J Virol 84(22): 11614-23.
  242. De Monte L, Reni M, Tassi E, Clavenna D, Papa I, Recalde H, Braga M, Di Carlo V, Doglioni C,Protti MP (2011). "Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer." J Exp Med 208(3): 469-78.
  243. "Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer." Nat Commun 2: 240.
  244. Gooden MJ, de Bock GH, Leffers N, Daemen T,Nijman HW (2011). "The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis." Br J Cancer 105(1): 93-103.
  245. Exley MA, Lynch L, Varghese B, Nowak M, Alatrakchi N,Balk SP (2011). "Developing understanding of the roles of CD1d-restricted T cell subsets in cancer: reversing tumor-induced defects." Clin Immunol 140(2): 184-95.
  246. Ray A,Dittel BN (2010). "Isolation of mouse peritoneal cavity cells." J Vis Exp(35).
  247. Li Z, Potts-Kant EN, Garantziotis S, Foster WM,Hollingsworth JW (2011). "Hyaluronan signaling during ozone-induced lung injury requires TLR4, MyD88, and TIRAP." PLoS One 6(11): e27137.
  248. Gutierrez C,Schiff R (2011). "HER2: biology, detection, and clinical implications." Arch Pathol Lab Med 135(1): 55-62.
  249. Seshacharyulu P, Ponnusamy MP, Haridas D, Jain M, Ganti AK,Batra SK (2012). "Targeting the EGFR signaling pathway in cancer therapy." Expert Opin Ther Targets 16(1): 15-31.
  250. Tait SW,Green DR (2012). "Mitochondria and cell signalling." J Cell Sci 125(Pt 4): 807-15.
  251. Jessy T (2011). "Immunity over inability: The spontaneous regression of cancer." J Nat Sci Biol Med 2(1): 43-9.
  252. Elvis AM,Ekta JS (2011). "Ozone therapy: A clinical review." J Nat Sci Biol Med 2(1): 66-70.
  253. Auerbach A,Hernandez ML (2012). "The effect of environmental oxidative stress on airway inflammation." Curr Opin Allergy Clin Immunol 12(2): 133-9.
  254. Enomoto K, Sho M, Wakatsuki K, Takayama T, Matsumoto S, Nakamura S, Akahori T, Tanaka T, Migita K, Ito M,Nakajima Y (2012). "Prognostic importance of tumour-infiltrating memory T cells in oesophageal squamous cell carcinoma." Clin Exp Immunol 168(2): 186-91.
  255. Rautava J,Syrjanen S (2012). "Biology of human papillomavirus infections in head and neck carcinogenesis." Head Neck Pathol 6 Suppl 1: S3-15.
  256. Lin Q, Chen H, Lu C, Wang B, Zhang Y, He X,Yu B (2011). "Effects of ozone on sciatic nerve in rat." Interv Neuroradiol 17(3): 281-5.
  257. Kirkwood JM, Butterfield LH, Tarhini AA, Zarour H, Kalinski P,Ferrone S (2012). "Immunotherapy of cancer in 2012." CA Cancer J Clin 62(5): 309-35.
  258. Schwartzentruber DJ, Lawson DH, Richards JM, Conry RM, Miller DM, Treisman J, Gailani F, Riley L, Conlon K, Pockaj B, Kendra KL, White RL, Gonzalez R, Kuzel TM, Curti B, Leming PD, Whitman ED, Balkissoon J, Reintgen DS, Kaufman H, Marincola FM, Merino MJ, Rosenberg SA, Choyke P, Vena D,Hwu P (2011). "gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma." N Engl J Med 364(22): 2119-27.
  259. Miao EA, Rajan JV,Aderem A (2011). "Caspase-1-induced pyroptotic cell death." Immunol Rev 243(1): 206-14.
  260. Wu L,Van Kaer L (2011). "Natural killer T cells in health and disease." Front Biosci (Schol Ed) 3: 236- 51.
  261. Senovilla L, Vacchelli E, Garcia P, Eggermont A, Fridman WH, Galon J, Zitvogel L, Kroemer G,Galluzzi L (2013). "Trial watch: DNA vaccines for cancer therapy." Oncoimmunology 2(4): e23803.
  262. Wathelet N,Moser M (2013). "Role of dendritic cells in the regulation of antitumor immunity." Oncoimmunology 2(4): e23973.
  263. Vacchelli E, Eggermont A, Fridman WH, Galon J, Tartour E, Zitvogel L, Kroemer G,Galluzzi L (2013). "Trial Watch: Adoptive cell transfer for anticancer immunotherapy." Oncoimmunology 2(5): e24238.
  264. Sunil VR, Patel-Vayas K, Shen J, Laskin JD,Laskin DL (2012). "Classical and alternative macrophage activation in the lung following ozone-induced oxidative stress." Toxicol Appl Pharmacol 263(2): 195-202.
  265. Markovic A,Chung CH (2012). "Current role of EGF receptor monoclonal antibodies and tyrosine kinase inhibitors in the management of head and neck squamous cell carcinoma." Expert Rev Anticancer Ther 12(9): 1149-59.
  266. Li Z, Tighe RM, Feng F, Ledford JG,Hollingsworth JW (2013). "Genes of innate immunity and the biological response to inhaled ozone." J Biochem Mol Toxicol 27(1): 3-16.
  267. Al-Hegelan M, Tighe RM, Castillo C,Hollingsworth JW (2011). "Ambient ozone and pulmonary innate immunity." Immunol Res 49(1-3): 173-91.
  268. Devaud C, John LB, Westwood JA, Darcy PK,Kershaw MH (2013). "Immune modulation of the tumor microenvironment for enhancing cancer immunotherapy." Oncoimmunology 2(8): e25961.
  269. Boucek J, Mrkvan T, Chovanec M, Kuchar M, Betka J, Boucek V, Hladikova M, Betka J, Eckschlager T,Rihova B (2010). "Regulatory T cells and their prognostic value for patients with squamous cell carcinoma of the head and neck." J Cell Mol Med 14(1-2): 426-33.
  270. Galluzzi L, Senovilla L, Vacchelli E, Eggermont A, Fridman WH, Galon J, Sautes-Fridman C, Tartour E, Zitvogel L,Kroemer G (2012). "Trial watch: Dendritic cell-based interventions for cancer therapy." Oncoimmunology 1(7): 1111-1134.
  271. Fujii SI, Shimizu K, Okamoto Y, Kunii N, Nakayama T, Motohashi S,Taniguchi M (2013). "NKT Cells as an Ideal Anti-Tumor Immunotherapeutic." Front Immunol 4: 409.
  272. Jiang P,Yue Y (2014). "Human papillomavirus oncoproteins and apoptosis (Review)." Exp Ther Med 7(1): 3-7.
  273. Neuzillet C, de Gramont A, Tijeras-Raballand A, de Mestier L, Cros J, Faivre S,Raymond E (2014). "Perspectives of TGF-beta inhibition in pancreatic and hepatocellular carcinomas." Oncotarget 5(1): 78-94.
  274. Feng F, Li Z, Potts-Kant EN, Wu Y, Foster WM, Williams KL,Hollingsworth JW (2012). "Hyaluronan activation of the Nlrp3 inflammasome contributes to the development of airway hyperresponsiveness." Environ Health Perspect 120(12): 1692-8.
  275. Qi W, Huang X,Wang J (2013). "Correlation between Th17 cells and tumor microenvironment." Cell Immunol 285(1-2): 18-22.
  276. Holbro T, Civenni G,Hynes NE (2003). "The ErbB receptors and their role in cancer progression." Exp Cell Res 284(1): 99-110.
  277. Guven A, Gundogdu G, Sadir S, Topal T, Erdogan E, Korkmaz A, Surer I,Ozturk H (2008). "The efficacy of ozone therapy in experimental caustic esophageal burn." J Pediatr Surg 43(9): 1679-84.
  278. Zhang B, Li P, Wang E, Brahmi Z, Dunn KW, Blum JS,Roman A (2003). "The E5 protein of human papillomavirus type 16 perturbs MHC class II antigen maturation in human foreskin keratinocytes treated with interferon-gamma." Virology 310(1): 100-8.
  279. Hernandez ML, Lay JC, Harris B, Esther CR, Jr., Brickey WJ, Bromberg PA, Diaz-Sanchez D, Devlin RB, Kleeberger SR, Alexis NE,Peden DB (2010). "Atopic asthmatic subjects but not atopic subjects without asthma have enhanced inflammatory response to ozone." J Allergy Clin Immunol 126(3): 537-44 e1.
  280. Yewale C, Baradia D, Vhora I, Patil S,Misra A (2013). "Epidermal growth factor receptor targeting in cancer: a review of trends and strategies." Biomaterials 34(34): 8690-707.
  281. Yu L, Wang L,Chen S (2013). "Dual character of Toll-like receptor signaling: pro-tumorigenic effects and anti-tumor functions." Biochim Biophys Acta 1835(2): 144-54.
  282. Singh AB,Harris RC (2005). "Autocrine, paracrine and juxtacrine signaling by EGFR ligands." Cell Signal 17(10): 1183-93.
  283. Roskoski R, Jr. (2013). "The ErbB/HER family of protein-tyrosine kinases and cancer." Pharmacol Res 79: 34-74.
  284. Sterz CM, Kulle C, Dakic B, Makarova G, Bottcher MC, Bette M, Werner JA,Mandic R (2010). "A basal- cell-like compartment in head and neck squamous cell carcinomas represents the invasive front of the tumor and is expressing MMP-9." Oral Oncol 46(2): 116-22.
  285. Gavert N,Ben-Ze'ev A (2008). "Epithelial-mesenchymal transition and the invasive potential of tumors." Trends Mol Med 14(5): 199-209.
  286. Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL,Spies T (1999). "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA." Science 285(5428): 727-9.
  287. Jiang J, Wu C,Lu B (2013). "Cytokine-induced killer cells promote antitumor immunity." J Transl Med 11: 83.
  288. "Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma." J Transl Med 9: 126.
  289. Braumuller H, Wieder T, Brenner E, Assmann S, Hahn M, Alkhaled M, Schilbach K, Essmann F, Kneilling M, Griessinger C, Ranta F, Ullrich S, Mocikat R, Braungart K, Mehra T, Fehrenbacher B, Berdel J, Niessner H, Meier F, van den Broek M, Haring HU, Handgretinger R, Quintanilla-Martinez L, Fend F, Pesic M, Bauer J, Zender L, Schaller M, Schulze-Osthoff K,Rocken M (2013). "T-helper-1-cell cytokines drive cancer into senescence." Nature 494(7437): 361-5.
  290. Shah P, Shyam AK,Shah S (2011). "Adjuvant combined ozone therapy for extensive wound over tibia." Indian J Orthop 45(4): 376-9.
  291. Benencia F, Sprague L, McGinty J, Pate M,Muccioli M (2012). "Dendritic cells the tumor microenvironment and the challenges for an effective antitumor vaccination." J Biomed Biotechnol 2012: 425476.
  292. Leon OS, Menendez S, Merino N, Castillo R, Sam S, Perez L, Cruz E,Bocci V (1998). "Ozone oxidative preconditioning: a protection against cellular damage by free radicals." Mediators Inflamm 7(4): 289-94.
  293. Koontongkaew S (2013). "The tumor microenvironment contribution to development, growth, invasion and metastasis of head and neck squamous cell carcinomas." J Cancer 4(1): 66-83.
  294. Alizadeh D, Katsanis E,Larmonier N (2013). "The multifaceted role of Th17 lymphocytes and their associated cytokines in cancer." Clin Dev Immunol 2013: 957878.
  295. Borrelli E, Diadori A, Zalaffi A,Bocci V (2012). "Effects of major ozonated autohemotherapy in the treatment of dry age related macular degeneration: a randomized controlled clinical study." Int J Ophthalmol 5(6): 708-13.
  296. "Papillomavirus E5: the smallest oncoprotein with many functions." Mol Cancer 10: 140.
  297. Cheng J,Fan XM (2013). "Role of cyclooxygenase-2 in gastric cancer development and progression." World J Gastroenterol 19(42): 7361-8.
  298. De Marchi E, Baldassari F, Bononi A, Wieckowski MR,Pinton P (2013). "Oxidative stress in cardiovascular diseases and obesity: role of p66Shc and protein kinase C." Oxid Med Cell Longev 2013: 564961.
  299. Bakkal BH, Gultekin FA, Guven B, Turkcu UO, Bektas S,Can M (2013). "Effect of ozone oxidative preconditioning in preventing early radiation-induced lung injury in rats." Braz J Med Biol Res 46(9): 789-96.
  300. Yung S,Chan TM (2011). "Pathophysiology of the peritoneal membrane during peritoneal dialysis: the role of hyaluronan." J Biomed Biotechnol 2011: 180594.
  301. Kundu SK,Nestor M (2012). "Targeted therapy in head and neck cancer." Tumour Biol 33(3): 707-21.
  302. Pilones KA, Aryankalayil J,Demaria S (2012). "Invariant NKT cells as novel targets for immunotherapy in solid tumors." Clin Dev Immunol 2012: 720803.
  303. Zamarron BF,Chen W (2011). "Dual roles of immune cells and their factors in cancer development and progression." Int J Biol Sci 7(5): 651-8.
  304. Apetoh L, Ghiringhelli F, Tesniere A, Obeid M, Ortiz C, Criollo A, Mignot G, Maiuri MC, Ullrich E, Saulnier P, Yang H, Amigorena S, Ryffel B, Barrat FJ, Saftig P, Levi F, Lidereau R, Nogues C, Mira JP, Chompret A, Joulin V, Clavel-Chapelon F, Bourhis J, Andre F, Delaloge S, Tursz T, Kroemer G,Zitvogel L (2007). "Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy." Nat Med 13(9): 1050-9.
  305. Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, Vermaelen K, Panaretakis T, Mignot G, Ullrich E, Perfettini JL, Schlemmer F, Tasdemir E, Uhl M, Genin P, Civas A, Ryffel B, Kanellopoulos J, Tschopp J, Andre F, Lidereau R, McLaughlin NM, Haynes NM, Smyth MJ, Kroemer G,Zitvogel L (2009). "Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors." Nat Med 15(10): 1170-8.
  306. Thielens A, Vivier E,Romagne F (2012). "NK cell MHC class I specific receptors (KIR): from biology to clinical intervention." Curr Opin Immunol 24(2): 239-45.
  307. Mudway IS,Kelly FJ (2000). "Ozone and the lung: a sensitive issue." Mol Aspects Med 21(1-2): 1-48.

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