Kristallstrukturen mit kleinen Sondenmolekülen: Ausleuchten von Bindetaschen, Startpunkt für ein Fragment-basiertes Wirkstoffdesign und Erhalten von Phaseninformationen zur Strukturlösung

Im Zuge dieser Doktorarbeit wurden unterschiedliche Bereiche behandelt, in denen die Proteinkristallographie wichtige Beiträge liefert. Angefangen bei der de novo Strukturaufklärung von Makromolekülen über Fragmentscreening mittels Röntgenstrukturanalyse bis hin zur strukturbasierten Entwicklung neu...

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1. Verfasser: Behnen, Jürgen
Beteiligte: Klebe, Gerhard (Prof.) (BetreuerIn (Doktorarbeit))
Format: Dissertation
Veröffentlicht: Philipps-Universität Marburg 2011
Pharmazeutische Chemie
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