Dokument

Summary:
Water stable and biodegradable nanofibers were successfully prepared by electrospinning of a combination of secondary aqueous dispersions of oligolactide (OLA) and a blockcopolyester. Stable aqueous dispersions of OLA up to 10 wt% loaded with the pheromone of Lobesia Botrana, the grapevine moth, were prepared using solvent displacement method. OLA was prepared by conventional polycondensation of lactic acid. The presence of OLA with hydrophilic alkoxy and carboxy end groups and pheromone as a secondary dispersion hydrophobe additive, succeeded in giving stable dispersions in water. Aqueous dispersion of a total hydrophobic content of up to 32 wt% was prepared applying the combination of solvent displacement method and osmosis. The average particle size of the dispersions was about 1-2 µm. No stable dispersions were possible without the pheromone or without the OLA. Replacement of the pheromone with classical hydrophobes used in miniemulsions for example hexadecane, hexadecanol (cetyl alcohol) did not yield stable dispersions. However, octyl acetate having structural analogy to the pheromone gave stable dispersions in water up to 10 wt%. This type of aqueous polyester formulation is highly effective in providing novel perspectives in applications such as controlled release of biomaterials like pheromone, in this case, and drugs. These could also be used for other processing techniques, for example, film preparation and coatings. Since such formulations completely eliminate the use of harmful organic solvents for processing, they can be highly effective for applications in the fields of medicine, pharmacy and agriculture.

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