Eine prospektive, kontrollierte Studie zur Wirksamkeit einer komplementären Adipositastherapie

Aktuelle Studien zeichnen ein alarmierendes Bild in Bezug auf Übergewicht und Adipositas der deutschen Bevölkerung. Neben den individuellen Belastungen für jeden Einzelnen sind auch die ökonomischen Auswirkungen auf das Gesundheitssystem als Ganzes signifikant. Adipositas hat sich in den letzten Ja...

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1. Verfasser: Louis, Janina Kristin
Beteiligte: Tebbe, J.J. (PD Dr. med.) (BetreuerIn (Doktorarbeit))
Format: Dissertation
Sprache:Deutsch
Veröffentlicht: Philipps-Universität Marburg 2010
Zahn-, Mund- u. Kieferheilkunde
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1. http://archiv.ub.uni-marburg.de/diss/z2008/0544


2. James, S. L. (1998). "Nitric oxide in health and disease." Parasitol Today. 14(12): 504.


3. Phillips, W., J. Schwarz, et al. (1991). "Linear gastric emptying of hyperosmolar glucose solutions." Nucl Med(32): 377-381.


4. Tschöp, M., C. Weyer, et al. (2001). "Circulating Ghrelin levels are decreased in human obesity." Diabetes. 50(4): 707-709.


5. Di Francesco, V., M. Zamboni, et al. (2005). "Delayed postprandial gastric emptying and impaired gallbladder contraction together with elevated cholecystokinin and peptide YY serum levels sustain satiety and inhibit hunger in healthy elderly persons." J Gerontol A Biol Sci Med Sci. 60(12): 1581-1585.


6. Konturek, P. C., J. W. Konturek, et al. (2005). "Neuro-hormonal control of food intake; basic mechanisms and clinical implications." Journal of Physiology and Pharmacology 56: 5-25.


7. Teff, K. L., S. S. Elliott, et al. (2004). "Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women." J Clin Endocrinol Metab. 89(6): 2963-2972.


8. Page, A. J., J. A. Slattery, et al. (2007). "Ghrelin selectively reduces mechanosensitivity of upper gastrointestinal vagal afferents." Am J Physiol Gastrointest Liver Physiol. 292(5): G1376-1384.


9. Krakamp, B., G. Diefenbach, et al. (2001). "Adipositastherapie-Plazebo-kontrollierte Dop- pelblindstudie zur Wirksamkeit von CM3." Der Kassenarzt. 11: 45-47.


10. Leibowitz, S. F. and J. T. Alexander (1991). "Analysis of neuropeptide Y-induced feeding: dissociation of Y1 and Y2 receptor effects on natural meal patterns." Peptides 12(6): 1251- 1260.


11. Marciani, L. Y., P.; Wright, J.; Moore, R.; Coleman, N.; Gowland, P.A.; Spiller, R.C. (2001). "Antral Motility Measurements by Magnetic Resonance Imaging." Neurogastroen- terology and Motility 13(5): 511-518.


12. Fouillet, H., C. Bos, et al. (2002). "Approaches to quantifying protein metabolism in re- sponse to nutrient ingestion." J Nutr. 132(10): 3208S-18S.


13. Cummings, D. E., J. Q. Purnell, et al. (2001). "A preprandial rise in plasma ghrelin levels suggests a role in meal initation in humans." Diabetes. 50(8): 1714-1719.


14. Foster, G. D., H. R. Wyatt, et al. (2003). "A randomized trial of a low-carbohydrate diet for obesity." N Engl J Med 348(21): 2082-2090.


15. Schmid, S. M., M. Hallschmid, et al. (2008). "A single night of sleep deprivation increases ghrelin levels and feelings of hunger in normal-weight healthy men." J Sleep Res. 17(3): 331-334.


16. Fryer, J. H., N. S. Moore, et al. (1955). "A study of the interrelationship of the energy- yielding nutrients, blood glucose levels, and subjective appetite in man." J Lab Clin Med. 45(5): 684-696.


17. Raskin, H. F. (1971). "Barium-burger roentgen study for unrecognized, clinically signifi- cant, gastric retention." South Med J. 64(10): 1227-1235.


18. Modlin, I. M., M. Kidd, et al. (2000). "Bayliss and Starling and the nascence of endocri- nology." Regul Pept. 93(1-3): 109-123.


19. Feinle, C., D. O'Donovan, et al. (2002). "Carbohydrate and Satiety." Nutrition Reviews 60: 155-169.


20. Hunter, R. G., K. Philpot, et al. (2004). "CART in feeding and obesity." Trends Endocrinol Metab. 15(9): 454-459.


21. Dominquez, G., A. Vicentic, et al. (2004). "CART peptides: modulators of mesolimbic dopamine, feeding, and stress." Ann N Y Acad Sci. 1025: 363-369.


22. Horowitz, B., S. M. Ward, et al. (1999). "Cellular and molecular basis for electrical rhyth- micity in gastrointestinal muscles." Annu Rev Physiol. 61: 19-43.


23. Morton, G. J., D. E. Cummings, et al. (2006). "Central nervous system control of food in- take and body weight." Nature 443: 289-295.


24. Kmiec, Z. (2006). "Central Regulation of food intake in ageing." Journal of Physiology and Pharmacology 57(6): 7-16.


25. Schwartz, M. W., E. Peskind, et al. (1996). "Cereprospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans." Nat Med 2: 589-593.


26. Elias, C. F., C. Lee, et al. (2001). "Characterization of CART neurons in the rat and human hypothalamus." J Comp Neurol. 432(1): 1-19.


27. Douglass, J. and S. Daoud (1996). "Characterization of the human cDNA and genomic DNA encording CART: a cocaine-and amphetamine-regulated transcript." Gene. 169(2): 241-245.


28. Ebbeling, C. B., D. B. Pawlak, et al. (2002). "Childhood obesity: public-health crisis, common sense cure." Lancet. 360(9331): 473-482.


29. Kameqai, J., H. Tamura, et al. (2001). "Chronic central infusion of ghrelin increases hypo- thalamic neropeptide Y and Agouti-related protein mRNA levels and body weight in rats." Diabetes. 50(11): 2438-2443.


30. Schoeller, D. A., J. F. Schneider, et al. (1977). "Clinical diagnosis with the stable isotope 13C in C02 breath tests: methodology and fundamental considerations. ." J Lab Clin Med. 90(3): 412-421.


31. Kelley, D. E., G. A. Bray, et al. (2002). "Clinical efficacy of orlistat therapy in overweight and obese patients with insulin-treated type 2 diabetes: A 1-year randomized controlled trial." Diabetes Care. 25(6): 1033-1041.


32. Okumura, T., H. Yamada, et al. (2000). "Cocaine-amphetamine-regulated transcript (CART) acts in the central nervous system to inhibit gastric acid secretion via brain corti- cotropin-releasing factor system." Endocrinology. 141(8): 2854-2860.


33. Couceyro, P., M. Paquet, et al. (1998). "Cocaine-and amphetamine-regulated transcript (CART) peptide immunoreactivity in myenteric plexus neurons of the rat ileum and co- localization with choline acetyltransferase." Synapse. 30(1): 1-8.


34. Hahn, T., J. F. Breininger, et al. (1998). "Coexpression of Agrp and NPY in fasting- activated hypothalamic neurons." Nature Neurosci. 1: 271-272.


35. Szewczyk, J. R. and D. D. Sternbach (2005). "Combating Obesity by Targeting Nuclear Receptors." Curr.Med.Chem.-Immun.,Endoc.&Metab.Agents 5: 73-84.


36. Fabris, S. M., A. C. Valezi, et al. (2006). "Computerized baropodometry in obese patients." Obes Surg. 16(12): 1574-1578.


37. Datz, F. L. (1991). "Considerations for accurately measuring gastric emptying." J Nucl Med. 32(5): 881-884.


38. Spencer, N. J. (2001). "Control of migrating motor activity in the colon." Curr Opin Phar- macol. 1(6): 604-610.


39. Krahn, D. D., B. A. Gosnell, et al. (1986). "CRF antagonist partially reverses CRF-and stress-induced effects on feeding." Brain Res Bull. 17(3): 285-289.


40. Schommartz, B. (2002). Der 13C-Oktansäure-Atemtest zur Messung der Magenentlee- rungszeit: Anwendung, Analytik, Auswertung. Medizinische Fakultät. Düsseldorf, Hein- rich-Heine-Universität.


41. Stubbs, R. J., L. M. O'Reilly, et al. (1999). "Description and evaluation of an experimental model to examine changes in selection between high-protein, high-carbohydrate and high- fat foods in humans." European journal of clinical nutrition 53(1): 13-21.


42. Pupovac, J. and G. H. Anderson (2002). "Dietary peptides induce satiety via chole- cystokinin-A and peripheral opioid receptors in rats." J Nutr. 132(9): 2775-2780.


43. Coenen, C., M. Wegener, et al. (1992). "Does physical exercises influence bowel transit time in healthy young men?" Am J Gastroenterol. 87(3): 292-295.


44. Burnstock, G. (1976). "Do some nerve cells release more than one transmitter?" Neurosci- ence. 1(4): 239-248.


45. Kastin, A. and W. Pan (2000). "Dynamic regulation of leptin entry into brain by the blood- brain-barrier." Regulat Pept 92: 37-43.


46. Berthold, H. K., S. Unverdorben, et al. (2008). "Effect of a cellulose-containing weight- loss supplement on gastric emptying and sensory functions." Obesity (Silver Spring). 16(10): 2272-2280.


47. Hall, J. A., T. N. Solie, et al. (1999). "Effect of acute gastric dilatation on gastric myoelec- tic and motor activity in dogs." Am J Vet Res. 60(5): 597-602.


48. Tataranni, P. and E. Ravussin (1997). "Effect of fat intake on energy balance." Annals of the New York Academy of Sciences 819(23): 37-43.


49. Oesch, S., C. Rüegg, et al. (2006). "Effect of gastric distension prior to eating on food in- take and feelings of satiety in humans." Physiol Behav. 87(5): 903-10.


50. Tümer, C., H. D. Oflazoğlu, et al. (2008). "Effect of ghrelin on gastric myoelectric activity and gastric emptying in rats." Regul Pept. 146(1-3): 26-32.


51. Mattes, R. D. (2007). "Effects of a combination fiber system on appetite and energy intake in overweight humans." Physiol Behav. 90(5): 705-711.


52. Balkan, B., E. Koyulu, et al. (2003). "Effects of adrenalectomy on CART expression in the rat arcuate nucleus." Synapse. 50(1): 14-19.


53. Madsen, J. L. (1992). "Effects of gender, age and body mass index on gastrointestinal tran- sit times." Dig Dis Sci. 37(10): 1548-1553.


54. Kachi, M., D. Shirasaka, et al. (2006). "Effects of Helicobacter pylori eradication therapy on gastric emptying measured using the 13C-octanoic acid breath test and the acetamino- phen method." J Gastroenterol Hepatol. 21(5): 824-830.


55. Berkowitz, R. I., K. Fujioka, et al. (2006). "Effects of sibutramine treatment in obese ado- lescents: a randomized trial." Ann Intern Med. 145(2): 81-90.


56. Van Gaal, L. F., A. M. Rissanen, et al. (2005). "Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight pa- tients: 1-year experience from the RIO-Europe study." Lancet. 365(9468): 1389-1397.


57. Cummings, D. E., K. Clement, et al. (2002). "Elevated plasma ghrelin levels in Prader Willi Syndrome." Nat Med. 8(7): 643-644.


58. Forbes, G. B., J. Gallup, et al. (1961). "Estimation of total body fat from potassium-40 con- tent." Science. 133: 101-102.


59. Arcano, S., E. Buonomo, et al. (2007). "Evaluation and prevention of type II diabetes mel- litus and cardiovascular diseases in obese children and adolescents: a public health inter- vention in a local health organisation in Rome (Italy)." Ig Sanita Pubbl. 63(3): 345-360.


60. Aziz, A. and G. H. Anderson (2003). "Exendin-4, a GLP-1 receptor agonist, interacts with proteins and their products of digestion to suppress food intake in rats." J Nutr. 133(7): 2326-2330.


61. Rehrer, N. J., E. Beckers, et al. (1989). "Exercise and training effects on gastric emptying of carbohydrate beverages." Med Sci Sports Exerc. 21(5): 540-549.


62. Friedman, M. I., R. B. Harris, et al. (1999). "Fatty acid oxidation affects food intake by altering hepatic energy status." Am J Physiol. 276 (4 Pt 2): 1046-1053.


63. Li, H. Y., H. W. Hwang, et al. (2002). "Functional characterizations of cocaine-and aphetamine-regulated transcript mRNA expression in the rat hypothalamus." Neurosci Lett. 323(3): 203-206.


64. Rao, S. S., S. Vemuri, et al. (2002). "Fundic balloon distension stimulates antral and duo- denal motility in man." Dig Dis Sci. 47(5): 1015-1019. .


65. Wang, G. J., D. Tomasi, et al. (2008). "Gastric distention activates satiety circuitry in the human brain." Neuroimage. 39(4): 1824-1831.


66. Matsumoto, M., R. Yoshimura, et al. (2007). "Gastric emptying in diabetic patients by the (13)C-octanoic acid breath test: role of insulin in gastric motility." J Gastroenterol. 42: 469-474.


67. Mudambo, K. S., G. P. Leese, et al. (1997). "Gastric emptying in soldiers during and after field exercise in the heat measured with the [13C]acetate breath test method." Eur J Appl Physiol Occup Physiol. 75(2): 109-114.


68. Hellmig, S., F. Von Schöniq, et al. (2006). "Gastric emptying time of fluids and solids in healthy subjects determined by 13C breath tests: influence of age, sex and body mass in- dex." J Gastroenterol Hepatol. 21(12): 1832-1838.


69. Haycock, G. B., G. J. Schwartz, et al. (1978). "Geometric method for measuring body sur- face area: a height-weight formula validated in infants, children, and adults." J Pediatr. 93(1): 62-66.


70. Ariga, H., Y. Nakade, et al. (2008). "Ghrelin accelerates gastric emptying via early mani- festation of antro-pyloric coordination in conscious rats." Regul Pept. 146(1-3): 112-6.


71. Date, Y., M. Kojima, et al. (2000). "Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans." Endocrinology. 141(11): 4255-4261.


72. Tebbe, J. J., S. Mronga, et al. (2005). "Ghrelin-Induced Stimulation of Colonic Propulsion is Dependent on Hypothalamic Neuropeptide Y1-and Corticotrophin-Relaesing Factor 1


73. Asakawa, A., A. Inui, et al. (2001). "Ghrelin is an appetite-stimulatory signal from stom- ach with structural resemblance to motilin." Gastroenterology. 120(2): 337-345.


74. Zheng, J., H. Ariga, et al. (2008). "Ghrelin regulates gastric phase III-like contractions in freely moving conscious mice." Neurogastroenterol Motil. 1365-2982.


75. Oomura, Y., T. Ono, et al. (1969). "Glucose and osmosensitive neurones of the rat hypo- thalamus." Nature 5190(222): 282-4.


76. Allescher, H.-D. (2000). Grundlagen der gastrointestinalen Motilität. Klinische Gastroente- rologie und Stoffwechsel. G. Adler, Beglinger, Manns, Müller-Lissner and Schmiegel.


77. Anderson, J. W., E. C. Konz, et al. (2000). "Health advantages and disadvantages of weight-reducing diets: a computer analysis and critical review." Journal of the American College of Nutrition 19(5): 578-590.


78. Kristensen, P., M. E. Judge, et al. (1998). "Hypothalamic CART is a new anorectic peptide regulated by leptin." Nature. 393(6680): 72-76.


79. Tremblay, A., G. Plourde, et al. (1989). "Impact of dietary fat content and fat oxidation on energy intake in humans." The American journal of clinical nutrition 49(5): 799-805.


80. Ritter, S., T. T. Dinh, et al. (1994). "Induction of Fos-like immunoreactivity (Fos-li) and stimulation of feeding by 2,5-anhydro-D-mannitol (2,5-AM) require the vagus nerve." Brain Res. 646(1): 53-64.


81. Hoad, C. L., P. Rayment, et al. (2004). "In vivo imaging of intragastric gelation and its effect on satiety in humans." J Nutr. 34(9): 2293-2300.


82. Niwano, Y., T. Adachi, et al. (2009). "Is glycemic index of food a feasible predictor of appetite, hunger, and satiety?" J Nutr Sci Vitaminol (Tokyo). 55(3): 201-207.


83. Koletzko, S., M. Haisch, et al. (1995). "Isotope-selective non-dispersive infrared spec- trometry for detection of Helicobacter pylori infection with 13C-urea breath test." Lancet. 345(8955): 961-962.


84. Craig, H. (1957). "Isotope standards for carbon and oxygen and correction factors for mass spectrometric analysis of carbon dioxide." Geochim Cosmichim Acta 12: 133-149.


85. Berson, S. A. and R. S. Yalow (1957). "Kinetics of reaction between insulin and insulin- binding antibody." J Clin Invest. 36: 873.


86. Elias, C. F., C. Lee, et al. (1998). "Leptin activates hypothalamic CART neurons projecting to the spinal cord." Neuron. 21(6): 1375-1385.


87. Peters, J. H., R. C. Ritter, et al. (2006). "Leptin and CCK selectively activate vagal afferent neurons innervating the stomach and duodenum." Am J Physiol Regul Integr Comp Physi- ol. 290(6): R1544-9.


88. Baskin, D. G., J. F. Breininger, et al. (1999). "Leptin receptor mRNA identifies a subpopu- lation of neuropeptide Y neurons activated by fasting in rat hypothalamus." Diabetes. 48: 828-833.


89. Zahn, A. L., C.D.; Hoffner, S.; Haberkorn, U.; Rating, D.; Haass, M.; Enck, P.; Stremmel, W.; Ruhl, A. (2003). "Measurement of Gastric Emptying by 13C-Octanoic Acid Breath Test Versus Scintigraphy in Diabetics." Z. Gastroenterol 41(5): 383-390.


90. Ehrlein, H., M. Schemann, et al. (1985). "Motor patterns of the canine small intestine." Elefteriou, F., J. D. Ahn, et al. (2005). "Leptin regulation of bone resorption by the sympa- thetic nervous system and CART." Nature. 434(7032): 514-520.


91. Spiess. J and W. Vale (1980). "Multiple forms of somatostatin-like activity in rat hypo- thalamus." Biochemistry. 19(13): 2861-2866.


92. Bauer, V. (1993). "NANC transmission in intestines and its pharmacological modulation." Acta Neurobiol Exp (Wars). 53(1): 65-77.


93. Grybäck, P., G. Hermanson, et al. (2000). "Nationwide standardisation and evaluation of scintigraphic gastric emptying: reference values and comparisons between subgroups in a multicentre trial." Eur J Nucl Med. 27(6): 647-655.


94. Moran, T. H. and G. J. Schwartz (1994). "Neurobiology of cholecystokinin." Crit Rev Neurobiol. 9(1): 1-28.


95. Valassi, E., M. Scacchi, et al. (2008). "Neuroendocrine control of food intake." Nutr Metab Cardiovasc Dis. 18(2): 158-168.


96. Vettor, R., R. Fabris, et al. (2002). "Neuroendocrine regulation of eating bahavior." J En- docrinol Invest (25): 836-854.


97. Hansen, M. B. (2003). "Neurohumoral control of gastrointestinal motility." Physiol Res. 52(1): 1-30.


98. Pfaffenbach, B., M. Wegener, et al. (1995). "Nicht-invasiver 13C-Oktansäureatemtest zur Messung der Magenentleerung einer festen Testmahlzeit-Korrelation mit der Szintigraphie bei Diabetikern und Reproduzierbarbeit bei gesunden Probanden." Z. Gastroeneterol. 33: 141-145.


99. Schmidthaus, C. (1999). NMR-Spektroskopische Detektion von Zuckern im Urin zur Per- meabilitätsbestimmung des gastrointestinalen Traktes. Fakultät für Chemie. Bochum, Ruhr-Universität Bochum.


100. Braden, B., S. Adams, et al. (1993). "Noninvasive 13C-acetate breath test for measuring gastric emptying: validation by simultaneous 99mTc-functional-scintigraphie and 13Co2- breath test in double tracer technique." Gastroenterology. 104,3: A481.


101. Kopelman, P. G. (2000). "Obesity as a medical problem." Nature 404(6778): 635-643.


102. Farrigan, C. and K. Pang (2002). "Obesity market overview." Nat Rev Drug Discov. 1(4): 257-258.


103. Kumanyika, S., R. W. Jeffery, et al. (2002). "Obesity prevention: the case for action." Int J Obes Relat Metab Disord. 26(3): 425-36.


104. "[13C]Octanoic Acid Breath Test for Gastric Emptying of Solids: Accuracy, Reproducibil- ity, and Comparison With Scintigraphy." Gastroenterology 112(4): 1155-1162.


105. Conze, J., C. J. Krones, et al. (2003). "Partial intestinal obstruction after swallowing a self- expanding sponge for weight reduction." Dtsch Med Wochenschr. 128(33): 1706-1708.


106. Solomon, A., B. A. De Fanti, et al. (2005). "Peripheral ghrelin participates in glucostatic feeding mechanisms and in the anorexigenic signalling mediated by CART and CRF neu- rons." Nutr Neurosci. 8((5-6)): 287-295.


107. Havel, P. J. (2001). "Peripheral Signals Conveying Metabolic Information to the Brain: Short-Term and Long-Term Regulation of Food Intake and Energy Homeostasis." Experi- mental biology and medicine (Maywood, N.J.) 226: 963-977.


108. Dunican, K. C., A. R. Desilets, et al. (2007). "Pharmacotherapeutic options for overweight adolescents." Ann Pharmacother. 41(9): 1445-1455.


109. Cummings, D. E., R. S. Frayo, et al. (2004). "Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time-and food-related cues." Am J Physiol Endocrinol Metab. 287(2): E297-304.


110. Müller, M. J. and S. Danielzik (2004). "Prävention ernährungsabhängiger Erkrankungen: Adipositas, Diabetes mellitus." Internist. 45: 168-172.


111. Patrono, C. and L. Bartalena (1987). Radioimmunoassay in basic and clinical pharmacol- ogy. Berlin [u.a.], Springer.


112. Williams, D. L. and D. E. Cummings (2005). "Regulation of ghrelin in physiologic and pathophysiologic states." J Nutr. 135(5): 1320-1325.


113. Schwartz, M. W., S. Woods, et al. (2000). "rewiew article Central nervous system control of food intake." Nature 404: 661-671.


114. Vanderwinden, J. M. (1999). "Role of Interstitial Cells of Cajal and their relationship with the enteric nervous system." Eur J Morphol. 37(4-5): 250-256.


115. Grill, H., Schwarz., et al. (2004). "Sensory neurobiological analysis of neuropeptide modu- lation of meal size." Physiology & Behavior 82: 81-87.


116. Considine, R. V., M. K. Sinah, et al. (1996). "Serum immunoreactive-leptin concentrations in normal-weight and obese humans." New Engl J Med(334): 292-295.


117. Woods, S. C., R. J. Seeley, et al. (1998). "Signals that regulate food intake and energy ho- meostasis." Science 280: 1378-1383.


118. Kojima, M. and K. Kangawa (2008). "Structure and function of ghrelin." Results Probl Cell Differ. 46: 89-115.


119. Vicentic, A., A. Lakatos, et al. (2006). "The CART receptors: background and recent ad- vances." Peptides. 27(8): 1934-7.


120. Olsson, C. and S. Holmgren (2001). "The control of gut motility." Comp Biochem Physiol A Mol Integr Physiol. 128(3): 481-503.


121. Itoh, H., J. Sakai, et al. (1995). "The control of smooth muscle tissues by nonadrenergic noncholinergic (NANC) nerve fibres in the autonomic nervous system." J Smooth Muscle Res. 31(3): 67-78.


122. Driver, C. J. (1988). "The effect of meal composition on the degree of satiation following a test meal and possible mechanisms involved." Br J Nutr. 60(3): 441-449.


123. Latner, J. D. and M. Schwartz (1999). "The effects of a high-carbohydrate, high-protein or balanced lunch upon later food intake and hunger ratings." Appetite 33(1): 119-128.


124. Anderson, G. H. and S. E. Moore (2004). "The Emerging Role of Dairy Proteins and Bio- active Peptides in Nutrition and Health." The Journal of Nutrition(Dietary Proteins in the Regulation of Food Intake and Body Weight in Humans): 974-979.


125. Kunze, W. A. and J. B. Furness (1999). "The enteric nervous system and regulation of in- testinal motility." Annu Rev Physiol. 61: 117-142.


126. Byrne, D. (2003). "The Eu and the obesity epidemic." Eurohelath 9.1: 16-17.


127. Stellar, E. (1954). "The physiology of motivation." Physiology & Behavior 61: 5-22.


128. Date, Y., N. Murakami, et al. (2002). "The role of the gastric afferent vagal nerve in ghre- lin-induced feeding and growth hormone secretion in rats." Gastroenterology. 123(4): 1120-1128.


129. Thim, L., P. Kristensen, et al. (1999). "Tissue-specific processing of cocaine-and am- phetamine-regulated transcript peptides in the rat." Proc Natl Acad Sci USA. 96(6): 2722- 2727.


130. Foschi, D., F. Corsi, et al. (2007). "Treatment of morbid obesity by intraparietogastric ad- ministration of botulinum toxin: a randomized, double-blind, controlled study." Int J Obes (Lond). 31(4): 707-712.


131. Darwiche, G. B., O.; Thorsson, O.; Almer, L.O. (2003). "Correlation Between Simultane- ous Scintigraphic and Ultrasonographic Measurement of Gastric Emptying in Patients With Type 1 Diabetes Mellitus." Journal of Ultrasound Medicine 22(5): 459-466.


132. Scheen, A. J. (2008). "CB1 receptor blockade and its impact on cardiometabolic risk fac- tors: overview of the RIO programme with rimonabant." J Neuroendocrinol. 20 suppl(1): 139-146.


133. Benninghoff and Drenckhahn (2002). Anatomie.


134. Bundesministerium für Gesundheit. (2007). "Daten und Fakten zu Ernährung und Bewe- gung." Retrieved 19.05., 2007, from http://www.bmg.bund.de/cln_040/nn_604742/DE/Themenschwerpunkte/Praevention/Gesu ndheitsvorsorge/daten-u-fakten-ernaehrung-bewegung.html.


135. Kojima, M., H. Hosoda, et al. (1999). "Ghrelin is a growth-hormone-releasing acylated peptide from stomach." Nature. 402(6762): 656-660.


136. Taché, Y., V. Martinez, et al. (2004). "CRF1 receptor signaling pathways are involved in stress-related alterations of colonic function and viscerosensitivity: implications for irrita- ble bowel syndrome." Br J Pharmacol. 141(8): 1321-1330.


137. Brain, S. D. and H. M. Cox (2006). "Neuropeptides and their receptors: innovative science providing novel therapeutic targets." Br J Pharmacol. 147 Suppl 1: 202-211.


138. Foster-Schubert., K. E., J. Overduin., et al. (2008). "Acyl and Total Ghrelin Are Sup- pressed Strongly by Ingested Proteins, Weakly by Lipids, and Biphasically by Carbohy- drates." The Journal of Clinical Endocrinology & Metabolism 93(5): 1971-1979.


139. Rogge, G., D. Jones, et al. (2008). "CART peptides: regulators of body weight, reward and other functions." Nat Rev Neurosci. 9(10): 747-758.


140. Masuda, Y., T. Tanaka, et al. (2000). "Ghrelin stimulates gastric acid secretion and motil- ity in rats." Biochem Biophys Res Commun. 276(3): 905-908.


141. Larsen, P. J., N. Vrang, et al. (2000). "Chronic intracerebroventricular administration of recombinant CART(42-89) peptide inhibits and causes weight loss in lean and obese Zucker (fa/fa) rats." Obes. Res. 8(8): 590-596.


142. Levin, F., T. Edholm, et al. (2006). "Ghrelin stimulates gastric emptying and hunger in normal-weight humans." J Clin Endocrinol Metab. 91(9): 3296-3302.


143. Ghoos, Y., B. Maes, et al. (1993). "Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test." Gastroenterology. 104: 1640-1647.